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Cholecalciferol Dosage

Applies to the following strength(s): 400 intl units/mL ; 1000 intl units ; 2000 intl units ; 400 intl units ; 5000 intl units ; 50,000 intl units ; 14,000 intl units ; 10,000 intl units/mL ; 4000 intl units ; 5000 intl units/mL ; 400 intl units/0.028 mL ; 1000 intl units/drop ; 10000 intl units ; 25,000 intl units ; 1000 intl units/10 mL

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Geriatric Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Vitamin D Insufficiency

600 to 2,000 international units, orally, once a day
Maximum dose: 4,000 international units per day

Usual Adult Dose for Vitamin D Deficiency

Initial dose:
50,000 international units, once a week, for 8 weeks
or
6,000 international units, once a day, for 8 weeks
Maintenance dose: 1,500 to 2,000 international units, once a day
Maximum dose: 10,000 international units per day

Comments:
-Target blood levels above 30 ng/mL of 25(OH)D.

Usual Adult Dose for Prevention of Falls

800 international units, orally, once a day
-1,500 to 2,000 international units, once a day, may be needed to achieve blood levels of 25(OH)D above 30 ng/mL.

Usual Geriatric Dose for Prevention of Fractures

Over 70 years: 800 to 2,000 international units, orally, once a day

Usual Pediatric Dose for Vitamin D Insufficiency

0 to 12 months: 400 international units once a day
1 to 18 years: 600 international units once a day

Maximum dose:
-Up to 6 months: 1,000 international units per day
-7 months to 1 year: 1,500 international units per day
-1 to 3 years: 2,500 international units per day
-4 to 8 years: 3,000 international units per day
-9 years and older: 4,000 international units per day

Usual Pediatric Dose for Vitamin D Deficiency

-Up to 1 year old: 2,000 international units, orally, once a day, for 6 weeks
or
50,000 international units, once a week, for 6 weeks
Maintenance dose: 400 to 1,000 international units per day

-1 to 18 years: 2,000 international units, orally, once a day for at least 6 weeks
or
50,000 international units, once a week, for at least 6 weeks
Maintenance dose: 600 to 1,000 international units per day

Maximum dose:
-Up to 1 year: 2,000 international units per day
-1 to 18 years: 4,000 international units per day

Comments:
-Target blood levels above 30 ng/mL of 25(OH)D.

Renal Dose Adjustments

Do not use in severe renal impairment

Liver Dose Adjustments

Data not available

Dose Adjustments

Pregnancy or Lactation: 600 to 2,000 international units once a day; maximum 4,000 international units per day
-1,500 to 2,000 international units, once a day, may be needed to achieve blood levels of 25(OH)D above 30 ng/mL.


Obesity, Malabsorption Syndromes, or Medications Affecting Vitamin D Absorption:
-Treatment of Deficiency: 6,000 to 10,000 international units, once a day, until blood levels of 25(OH)D are above 30 ng/mL.
-Maintenance dose: 1,500 to 2,000 international units, once a day

Patients on anticonvulsants, glucocorticoids, antifungals such as ketoconazole, or medications for acquired immune deficiency syndrome may require 2 to 3 times more vitamin D.

Provide medical supervision if upper limits are exceeded.

Dialysis

Vitamin D and its metabolites are not dialyzable.

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