Amvuttra Disease Interactions
There are 2 disease interactions with Amvuttra (vutrisiran).
Moderate
Vutrisiran (applies to Amvuttra) liver dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Vutrisiran has not been studied in patients with severe hepatic impairment, or in patients with prior liver transplant.
References (1)
- (2025) "Product Information. Amvuttra (vutrisiran)." Alnylam Pharmaceuticals
Moderate
Vutrisiran (applies to Amvuttra) renal dysfunction
Moderate Potential Hazard, Moderate plausibility.
Vutrisiran has not been studied in patients with severe renal dysfunction, or end-stage renal disease.
References (1)
- (2025) "Product Information. Amvuttra (vutrisiran)." Alnylam Pharmaceuticals
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- Drug class: miscellaneous metabolic agents
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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