Amvuttra Disease Interactions
There are 2 disease interactions with Amvuttra (vutrisiran).
Vutrisiran (applies to Amvuttra) liver dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Vutrisiran has not been studied in patients with severe hepatic impairment, or in patients with prior liver transplant.
References (1)
- (2025) "Product Information. Amvuttra (vutrisiran)." Alnylam Pharmaceuticals
Vutrisiran (applies to Amvuttra) renal dysfunction
Moderate Potential Hazard, Moderate plausibility.
Vutrisiran has not been studied in patients with severe renal dysfunction, or end-stage renal disease.
References (1)
- (2025) "Product Information. Amvuttra (vutrisiran)." Alnylam Pharmaceuticals
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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