Amvuttra Side Effects

Generic name: vutrisiran

Medically reviewed by Drugs.com. Last updated on Oct 30, 2023.

Note: This document provides detailed information about Amvuttra.

Applies to vutrisiran: subcutaneous solution Side Effects associated with vutrisiran. Some dosage forms listed on this page may not apply specifically to the brand name Amvuttra.

Applies to vutrisiran: subcutaneous solution.

Precautions

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

This medicine may lower the vitamin A levels in your body, which may cause eye or vision problems (eg, night blindness, blurred vision, difficulty with reading, or any other change in vision). Your doctor may want your eyes be checked by an ophthalmologist (eye doctor).

Serious side effects of Amvuttra

Along with its needed effects, vutrisiran (the active ingredient contained in Amvuttra) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking vutrisiran:

Other side effects of Amvuttra

Some side effects of vutrisiran may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to vutrisiran: subcutaneous solution.

General adverse events

The most common adverse reactions were pain in extremity, arthralgia, dyspnea, and decrease in vitamin A levels.^[Ref]

Cardiovascular

• Common (1% to 10%): Atrioventricular heart block^[Ref]

Local

• Common (1% to 10%): Injection site reactions (bruising, erythema, pruritus, warmth)^[Ref]

Metabolic

• Very common (10% or more): Decreased vitamin A (80%)
• Common (1% to 10%): Increased blood alkaline phosphatase^[Ref]

Musculoskeletal

• Very common (10% or more): Pain in extremity (15%), arthralgia (11%)^[Ref]

Respiratory

• Common (1% to 10%): Dyspnea^[Ref]

See also:

Further information

Amvuttra side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer