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Valganciclovir Disease Interactions

There are 3 disease interactions with valganciclovir:

Moderate

Valganciclovir (Includes Valganciclovir) ↔ Hematologic Toxicities

Moderate Potential Hazard, Moderate plausibility

Applies to: Neutropenia, Anemia, Thrombocytopenia, Pancytopenia, Aplastic Anemia, Bone Marrow Depression/Low Blood Counts

Severe leukopenia, neutropenia, anemia, thrombocytopenia, pancytopenia, bone marrow aplasia, and aplastic anemia have been reported in patients treated with valganciclovir. The use of this agent should be avoided if the absolute neutrophil count is less than 500 cells/µL, the platelet count is less than 25,000/µ/L, or the hemoglobin is less than 8 g/dL. Complete blood counts with differential and platelet counts should be performed frequently, especially in patients that developed leukopenia after using a nucleoside analog, or in whom neutrophil counts are less than 1000 cells/µL at the beginning of treatment. Increased monitoring is recommended.

Moderate

Valganciclovir (Includes Valganciclovir) ↔ Hepatic Impairment

Moderate Potential Hazard, Moderate plausibility

Applies to: Liver Disease

Monitoring is recommended when using valganciclovir in patients with hepatic impairment as the safety and efficacy of this agent has not been studied in these patients.

Moderate

Valganciclovir (Includes Valganciclovir) ↔ Renal Impairment

Moderate Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction, hemodialysis, Dehydration

Acute renal failure has been documented in elderly patients (with or without reduced renal function), patients who receive concomitant nephrotoxic drugs, or inadequately hydrated patients. Adequate hydration, dose reduction and close monitoring of renal function are recommended when using valganciclovir in these patients. The tablet form of valganciclovir should not be used in adult patients on hemodialysis (CrCl less than 10 mL/min).

valganciclovir drug Interactions

There are 177 drug interactions with valganciclovir

valganciclovir alcohol/food Interactions

There is 1 alcohol/food interaction with valganciclovir

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2017 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

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