Tepotinib Disease Interactions
There are 3 disease interactions with tepotinib:
Tepotinib (Includes tepotinib) ILD/pneumonitis
Moderate Potential Hazard, Moderate plausibility. Applies to: Pulmonary Impairment
The use of tepotinib may cause interstitial lung disease (ILD)/pneumonitis, sometimes resulting in fatalities. Care should be exercised when using this drug in patients with preexisting pulmonary impairment. Immediately withhold treatment in patients with suspected ILD/pneumonitis and permanently discontinue if no other potential causes of ILD/pneumonitis are identified. It is recommended to monitor for new or worsening pulmonary symptoms indicative of ILD/pneumonitis.
Tepotinib (Includes tepotinib) live dysfunction
Moderate Potential Hazard, Moderate plausibility. Applies to: Liver Disease
The use of tepotinib may cause hepatotoxicity, sometimes resulting in fatalities. No dosage modification is recommended in patients with mild (Child-Pugh Class A) or moderate (Child-Pugh Class B) hepatic impairment. Care should be exercised when using tepotinib in patients with severe hepatic impairment (Child-Pugh C) as its pharmacokinetics and safety have not been studied in this patient population. It is recommended to monitor liver function tests, including ALT, AST, and total bilirubin prior to the start of therapy, every 2 weeks during the first 3 months of treatment, then once a month or as clinically indicated, with more frequent testing in patients who develop increased transaminases or bilirubin. Withhold, reduce the dose, or permanently discontinue treatment based on the severity of the adverse reactions.
Tepotinib (Includes tepotinib) renal dysfunction
Moderate Potential Hazard, Moderate plausibility. Applies to: Renal Dysfunction
Care should be exercised when using tepotinib in patients with severe renal dysfunction (CrCl less than 30 mL/min) as the recommended dosage has not been established in this patient population. No dosage adjustment is recommended in patients with mild or moderate renal impairment (CrCl 30 to 89 mL/min).
Tepotinib drug interactions
There are 233 drug interactions with tepotinib
Tepotinib alcohol/food interactions
There is 1 alcohol/food interaction with tepotinib
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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