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Tepotinib Disease Interactions

There are 3 disease interactions with tepotinib:

Moderate

Tepotinib (Includes tepotinib) ILD/pneumonitis

Moderate Potential Hazard, Moderate plausibility. Applies to: Pulmonary Impairment

The use of tepotinib may cause interstitial lung disease (ILD)/pneumonitis, sometimes resulting in fatalities. Care should be exercised when using this drug in patients with preexisting pulmonary impairment. Immediately withhold treatment in patients with suspected ILD/pneumonitis and permanently discontinue if no other potential causes of ILD/pneumonitis are identified. It is recommended to monitor for new or worsening pulmonary symptoms indicative of ILD/pneumonitis.

Moderate

Tepotinib (Includes tepotinib) live dysfunction

Moderate Potential Hazard, Moderate plausibility. Applies to: Liver Disease

The use of tepotinib may cause hepatotoxicity, sometimes resulting in fatalities. No dosage modification is recommended in patients with mild (Child-Pugh Class A) or moderate (Child-Pugh Class B) hepatic impairment. Care should be exercised when using tepotinib in patients with severe hepatic impairment (Child-Pugh C) as its pharmacokinetics and safety have not been studied in this patient population. It is recommended to monitor liver function tests, including ALT, AST, and total bilirubin prior to the start of therapy, every 2 weeks during the first 3 months of treatment, then once a month or as clinically indicated, with more frequent testing in patients who develop increased transaminases or bilirubin. Withhold, reduce the dose, or permanently discontinue treatment based on the severity of the adverse reactions.

Moderate

Tepotinib (Includes tepotinib) renal dysfunction

Moderate Potential Hazard, Moderate plausibility. Applies to: Renal Dysfunction

Care should be exercised when using tepotinib in patients with severe renal dysfunction (CrCl less than 30 mL/min) as the recommended dosage has not been established in this patient population. No dosage adjustment is recommended in patients with mild or moderate renal impairment (CrCl 30 to 89 mL/min).

Tepotinib drug interactions

There are 233 drug interactions with tepotinib

Tepotinib alcohol/food interactions

There is 1 alcohol/food interaction with tepotinib

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.