Xermelo (telotristat) Disease Interactions
There are 3 disease interactions with Xermelo (telotristat):
Telotristat (applies to Xermelo) constipation
Moderate Potential Hazard, Moderate plausibility.
The use of telotristat reduces bowel movement frequency and may cause gastrointestinal effects including, constipation, intestinal perforation and obstruction. It is recommended to monitor for the development of constipation and/or severe, persistent, or worsening abdominal pain in patients taking telotristat and to discontinue its use if severe constipation or severe persistent or worsening abdominal pain develops. Care is recommended when using telotristat in patients suffering from constipation. .
Telotristat (applies to Xermelo) hepatic impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Population pharmacokinetic analysis showed that mild hepatic impairment does not affect the pharmacokinetics of telotristat. Care is recommended when using telotristat in patients with moderate or severe hepatic impairment as this agent has not been studied in this patient population.
Telotristat (applies to Xermelo) renal dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: hemodialysis
Population pharmacokinetic (PK) analysis showed that creatine clearance does not affect the PK of telotristat. Care is recommended when using telotristat in patients with end-stage renal disease (ESRD) who require dialysis as this agent has not been studied in this patient population.
Xermelo (telotristat) drug interactions
There are 310 drug interactions with Xermelo (telotristat)
Xermelo (telotristat) alcohol/food interactions
There are 2 alcohol/food interactions with Xermelo (telotristat)
More about Xermelo (telotristat)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Pricing & Coupons
- En Español
- 1 Review
- Drug class: miscellaneous GI agents
- FDA Approval History
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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