Skip to Content

Xermelo Side Effects

Generic Name: telotristat

Note: This document contains side effect information about telotristat. Some of the dosage forms listed on this page may not apply to the brand name Xermelo.

For the Consumer

Applies to telotristat: oral tablet

Along with its needed effects, telotristat (the active ingredient contained in Xermelo) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking telotristat:

Incidence not known
  • Severe constipation
  • severe stomach pain

Some side effects of telotristat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • decreased appetite
  • discouragement
  • excess air or gas in the stomach or intestines
  • feeling sad or empty
  • fever
  • full feeling
  • headache
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • nausea
  • passing gas
  • rapid weight gain
  • tingling of the hands or feet
  • tiredness
  • trouble concentrating
  • trouble sleeping
  • unusual weight gain or loss

For Healthcare Professionals

Applies to telotristat: oral tablet


The most commonly reported side effects include nausea, headache, increased gamma-glutamyltransferase (GGT) and depression.[Ref]


Very common (10% or more): Nausea (up to 13%)
Common (1% to 10%): Flatulence, abdominal distention, gastrointestinal pain, constipation, abdominal pain/upper and lower abdominal pain
Frequency not reported: Fecaloma[Ref]

Nervous system

Very common (10% or more): Headache (up to 11%)[Ref]


Common (1% to 10%): Increased gamma-glutamyltransferase (GGT)
Frequency not reported: Increased alkaline phosphatase, increased alanine aminotransferase, increased aspartate aminotransferase[Ref]


Common (1% to 10%): Depression[Ref]


Common (1% to 10%): Peripheral edema[Ref]


Common (1% to 10%): Decreased appetite[Ref]


Common (1% to 10%): Pyrexia[Ref]


1. "Product Information. Xermelo (telotristat ethyl)." Lexicon Pharmaceuticals, Inc., The Woodlands, TX.

Some side effects of Xermelo may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.