Skip to Content

Kayexalate (sodium polystyrene sulfonate) Disease Interactions

There are 3 disease interactions with Kayexalate (sodium polystyrene sulfonate):

Major

Sodium Polystyrene Sulfonate (Includes Kayexalate) ↔ Hypokalemia

Severe Potential Hazard, High plausibility

Applies to: Hypokalemia

The use of sodium polystyrene sulfonate is contraindicated in patients with hypokalemia. Serious potassium deficiency can occur from therapy with sodium polystyrene sulfonate. Sodium polystyrene sulfonate exchanges sodium ions for potassium ions in the intestine or colon. Monitoring serum potassium levels carefully and evaluating the patient's clinical condition and electrocardiogram may be necessary.

References

  1. Meyer I "Sodium polystyrene sulfonate: a cation exchange resin used in treating hyperkalemia." ANNA J 20 (1993): 93-5
  2. "Product Information. Kayexalate (sodium polystyrene sulfonate)." Sanofi Winthrop Pharmaceuticals, New York, NY.
Major

Sodium Polystyrene Sulfonate (Includes Kayexalate) ↔ Obstructive Bowel Disease

Severe Potential Hazard, Moderate plausibility

Applies to: Intestinal Obstruction

The use of sodium polystyrene sulfonate is contraindicated in patients with obstructive bowel disease. Cases of intestinal necrosis, which may be fatal, and other serious gastrointestinal adverse events (bleeding, ischemic colitis, perforation) have been reported in association with sodium polystyrene sulfonate use. Therapy with this agent should be avoided in patients who have not had a bowel movement post-surgery, and patients who are at risk of developing constipation or impaction. Therapy with sodium polystyrene sulfonate should be discontinued in patients who develop constipation during treatment.

Major

Sodium Polystyrene Sulfonate (Includes Kayexalate) ↔ Sodium Load

Severe Potential Hazard, Moderate plausibility

Applies to: Hypertension, Congestive Heart Failure, Fluid Retention

The use of sodium polystyrene sulfonate is associated with an elevation in sodium. Therapy with sodium polystyrene sulfonate should be administered cautiously in patients with conditions that might be exacerbated by additional sodium such as severe congestive heart failure, severe hypertension, or marked edema. Compensatory restriction of sodium intake from other sources may be indicated.

References

  1. "Product Information. Kayexalate (sodium polystyrene sulfonate)." Sanofi Winthrop Pharmaceuticals, New York, NY.
  2. Meyer I "Sodium polystyrene sulfonate: a cation exchange resin used in treating hyperkalemia." ANNA J 20 (1993): 93-5

Kayexalate (sodium polystyrene sulfonate) drug Interactions

There are 164 drug interactions with Kayexalate (sodium polystyrene sulfonate)

Kayexalate (sodium polystyrene sulfonate) alcohol/food Interactions

There are 3 alcohol/food interactions with Kayexalate (sodium polystyrene sulfonate)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2018 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

Hide