Setmelanotide Disease Interactions
There are 2 disease interactions with setmelanotide.
Setmelanotide (applies to setmelanotide) depression
Moderate Potential Hazard, Moderate plausibility.
Adult and pediatric patients treated with setmelatonide may experience worsening depression and may have the emergence of suicidal thoughts and behavior. Patients should be monitored appropriately and observed closely for worsening depression, suicidality or changes in their behavior. Therapy discontinuation should be considered if patients experience suicidal thoughts or behaviors.
Setmelatonide (applies to setmelanotide) renal impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
Setmelatonide is not recommended in patients with moderate (eGFR 30-59 mL/min/1.73 m2 ) and severe renal impairment (eGFR 15-29 mL/min/1.73 m2 ) and end stage renal disease (eGFR less than 15 mL/min/1.73 m2 ).
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- Drug class: melanocortin receptor agonists
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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