Romidepsin Disease Interactions
There are 5 disease interactions with romidepsin:
Romidepsin (Includes Romidepsin) ↔ Hepatic Impairment
Moderate Potential Hazard, Moderate plausibility
Applies to: Liver Disease
Romidepsin population pharmacokinetic analysis indicated that mild hepatic impairment had no significant influence on romidepsin pharmacokinetics. Care and close monitoring of liver function is recommended in patients with moderate and severe hepatic impairment as the pharmacokinetics of romidepsin is unknown in these patients.
Romidepsin (Includes Romidepsin) ↔ Infections
Moderate Potential Hazard, Moderate plausibility
Applies to: Infection - Bacterial/Fungal/Protozoal/Viral
Cases of fatal and serious infections, including pneumonia, sepsis, and viral reactivation, including Epstein Barr and hepatitis B viruses have been reported with the use of romidepsin. The risk of life threatening infections may be greater in patients with a history of prior treatment with monoclonal antibodies directed against lymphocyte antigens and in patients with disease involvement of the bone marrow. Monitor reactivation in patients with evidence of prior hepatitis B infection as recommended and consider antiviral prophylaxis as clinically indicated.
Romidepsin (Includes Romidepsin) ↔ Myelosuppression
Moderate Potential Hazard, Moderate plausibility
Applies to: Neutropenia, Thrombocytopenia, Lymphocytopenia
The use of remidepsin may cause thrombocytopenia, leukopenia (neutropenia and lymphopenia), and anemia. It is recommended to monitor blood counts regularly during treatment, and if necessary to modify the dose of remidepsin according to clinical practices.
Romidepsin (Includes Romidepsin) ↔ Qt Prolongation
Moderate Potential Hazard, Moderate plausibility
Applies to: Arrhythmias, Cardiovascular Disease
The use of romidepsin may cause changes in ECG. It is recommended to consider cardiovascular monitoring of ECG prior to starting therapy and periodically during treatment in patients with congenital long QT syndrome, history of significant cardiovascular disease, and in patients taking anti-arrhythmic medicines or medicinal products that lead to significant QT prolongation. Confirm that potassium and magnesium levels are within normal range before administration of romidepsin. Care and close monitoring is recommended.
Romidepsin (Includes Romidepsin) ↔ Renal Impairment
Moderate Potential Hazard, Moderate plausibility
Applies to: Renal Dysfunction
Romidepsin population pharmacokinetic analysis indicated that romidepsin pharmacokinetics were not affected by renal impairment. Care and close monitoring is recommended when prescribing this agent to patients with end-stage renal disease as the pharmacokinetics of romidepsin have not been studied in these patients.
romidepsin drug Interactions
There are 460 drug interactions with romidepsin
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No information available. |
Do not stop taking any medications without consulting your healthcare provider.
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