Ravulizumab Disease Interactions
There are 3 disease interactions with ravulizumab:
Ravulizumab (applies to ravulizumab) meningitis
Major Potential Hazard, Moderate plausibility. Applicable conditions: CNS Infection
Ravulizumab is contraindicated in patients with unresolved Neisseria meningitidis infection. Life-threatening meningococcal infections have occurred in patients treated with ravulizumab, and the drug has shown to increases patient's susceptibility to serious meningococcal infections (septicemia and/or meningitis). Patients that will receive treatment should be vaccinated for meningococcal disease according to the most current Advisory Committee on Immunization Practices (ACIP) recommendations for patients with complement deficiencies, and revaccinated in accordance with ACIP recommendations considering the duration of ravulizumab therapy. Immunize patients without a history of meningococcal vaccination at least 2 weeks prior to receiving the first dose of ravulizumab. If urgent ravulizumab therapy is indicated in an unvaccinated patient, meningococcal vaccine(s) should be administered as soon as possible with 2 weeks of antibacterial drug prophylaxis. Patients receiving ravulizumab, should be closely monitored for early signs and symptoms of meningococcal infection and if infection is suspected patients need immediate evaluation.
Ravulizumab (applies to ravulizumab) infections
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Infection - Bacterial/Fungal/Protozoal/Viral
Ravulizumab blocks terminal complement activation; therefore, patients may have increased susceptibility to encapsulated bacteria infections, especially infections caused by Neisseria meningitidis but also Streptococcus pneumoniae, Haemophilus influenzae, and to a lesser extent, Neisseria gonorrhoeae. If ravulizumab therapy is administered to patients with active systemic infections, monitor closely for signs and symptoms of worsening infection.
Ravulizumab (applies to ravulizumab) severe renal impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
The effect of severe renal impairment (eGFR 15 to 29 mL/min/1.73 m2) on ravulizumab pharmacokinetics is unknown.
Ravulizumab drug interactions
There are 4 drug interactions with ravulizumab
More about ravulizumab
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- En Español
- Drug class: selective immunosuppressants
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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