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Ravulizumab use while Breastfeeding

Medically reviewed by Drugs.com. Last updated on Mar 9, 2024.

Drugs containing Ravulizumab: Ultomiris

Ravulizumab Levels and Effects while Breastfeeding

Summary of Use during Lactation

No information is available on the use of ravulizumab during breastfeeding. Because ravulizumab is a large protein molecule with a molecular weight of about 148,000 Da, absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. Waiting for at least 2 weeks postpartum to resume therapy may minimize transfer to the infant.[1] The manufacturer recommends that breastfeeding be discontinued during ravulizumab therapy and for 8 months after the final dose.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Eculizumab

References

1.
Krysko KM, Dobson R, Alroughani R, et al. Family planning considerations in people with multiple sclerosis. Lancet Neurol. 2023;22:350–66. [PubMed: 36931808]

Substance Identification

Substance Name

Ravulizumab

CAS Registry Number

1803171-55-2

Drug Class

Breast Feeding

Lactation

Milk, Human

Antibodies, Monoclonal

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Further information

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