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Probenecid Disease Interactions

There are 5 disease interactions with probenecid.

Major

Probenecid (applies to probenecid) blood dyscrasias

Major Potential Hazard, Moderate plausibility. Applicable conditions: Anemia, Bone Marrow Depression/Low Blood Counts

The manufacturer does not recommend the use of probenecid in patients with known blood dyscrasias. Aplastic anemia, leukopenia, hemolytic anemia and other anemia have been reported infrequently during administration of probenecid. Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency may increase the risk of probenecid-induced hemolytic anemia.

References (4)
  1. Sosler SD, Behzad O, Garratty G, et al. (1985) "Immune hemolytic anemia associated with probenecid." Am J Clin Pathol, 84, p. 391-4
  2. Kickler TS, Buck S, Ness P, et al. (1986) "Probenecid induced immune hemolytic anemia." J Rheumatol, 13, p. 208-9
  3. Gutman AB (1966) "Uricosuric drugs with special reference to probenecid and sulfinpyrazone." Adv Pharmacol, 4, p. 91-142
  4. (2001) "Product Information. Benemid (probenecid)." Merck & Co., Inc
Major

Probenecid (applies to probenecid) dehydration

Major Potential Hazard, High plausibility. Applicable conditions: Diarrhea, Vomiting

Probenecid may promote lithiasis by increasing uric acid concentration in the renal tubules. Adequate hydration is necessary during therapy. Patients who are dehydrated (e.g., due to severe diarrhea or vomiting) may be at increased risk for the development of uric acid kidney stones and should be encouraged to consume additional amounts of liquid or given intravenous fluid. In general, fluid intake sufficient to yield a daily urinary output of at least 2 liters is recommended. Maintenance of a slightly alkaline or neutral urine is also desirable.

References (2)
  1. Gutman AB (1966) "Uricosuric drugs with special reference to probenecid and sulfinpyrazone." Adv Pharmacol, 4, p. 91-142
  2. (2001) "Product Information. Benemid (probenecid)." Merck & Co., Inc
Major

Probenecid (applies to probenecid) uric acid nephrolithiasis

Major Potential Hazard, High plausibility. Applicable conditions: History - Nephrolithiasis, Gouty Nephropathy

The use of probenecid is not recommended in patients with a history of uric acid nephrolithiasis or a urinary urate excretion greater than 750 mg/24 hr. Probenecid may promote lithiasis by increasing uric acid concentration in the renal tubules. Adequate hydration is necessary during treatment. In general, a fluid intake sufficient to yield a daily urinary output of at least 2 liters is recommended. Maintenance of a slightly alkaline urine is also desirable.

References (2)
  1. Gutman AB (1966) "Uricosuric drugs with special reference to probenecid and sulfinpyrazone." Adv Pharmacol, 4, p. 91-142
  2. (2001) "Product Information. Benemid (probenecid)." Merck & Co., Inc
Moderate

Probenecid (applies to probenecid) PUD

Moderate Potential Hazard, Low plausibility. Applicable conditions: Peptic Ulcer, History - Peptic Ulcer

The manufacturer states that probenecid should be used with caution in patients with a history of peptic ulcer. Uricosuric agents can cause upper gastrointestinal irritation and aggravate or reactivate peptic ulcer. However, these effects have primarily been reported with another uricosuric agent, sulfinpyrazone. GI effects associated with probenecid are usually limited to nausea, vomiting, and anorexia.

References (1)
  1. (2001) "Product Information. Benemid (probenecid)." Merck & Co., Inc
Moderate

Probenecid (applies to probenecid) renal dysfunction

Moderate Potential Hazard, High plausibility.

Probenecid may not be effective in patients with chronic renal insufficiency, particularly when glomerular filtration rate is 30 mL/min or less. Probenecid has been used in patients with some renal impairment but dosage requirements may be increased.

References (2)
  1. Scott JT, O'Brien PK (1968) "Probenecid, nephrotic syndrome, and renal failure." Ann Rheum Dis, 27, p. 249-52
  2. (2001) "Product Information. Benemid (probenecid)." Merck & Co., Inc

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Probenecid drug interactions

There are 178 drug interactions with probenecid.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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