Skip to Content

Posaconazole Disease Interactions

There are 3 disease interactions with posaconazole:

Moderate

Azole antifungals (applies to posaconazole) QT prolongation

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Arrhythmias

Some azole antifungals have been associated with prolongation of the QT interval on the ECG. Rare cases of QT prolongation and torsade de pointes have been reported during postmarketing experience; such reports usually involved seriously ill patients with multiple confounding risk factors, such as structural heart disease, electrolyte abnormalities, and concomitant medications. These drugs should be administered with caution to patients with potentially proarrhythmic conditions. Concomitant use with other medications that have potential to increase the risk of cardiotoxicity should be avoided.

Moderate

Posaconazole (applies to posaconazole) hepatotoxicity

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

The use of posaconazole has been associated with hepatic adverse reactions and hepatic toxicity. Liver function tests should be performed at the start of therapy and periodically in patients with preexisting hepatic abnormalities. Treatment should be withdrawn if persistent elevations or worsening of liver enzyme levels occur and clinical signs and symptoms consistent with liver disease develop.

Moderate

Posaconazole (applies to posaconazole) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

Posaconazole injection should be avoided in patients with moderate to severe renal impairment (GRF <50 mL/min), unless an assessment of the risks and benefits justifies its use. If used, serum creatinine levels should be closely monitored. No dose adjustment is needed in patients with mild or moderate renal dysfunction using oral suspension. Patients with severe renal dysfunction should be closely monitored for breakthrough fungal infections due to a variability in exposure. Similar recommendations apply for posaconazole delayed-release tablets although specific studies have not been conducted.

Posaconazole drug interactions

There are 523 drug interactions with posaconazole

Posaconazole alcohol/food interactions

There is 1 alcohol/food interaction with posaconazole

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.