Posaconazole Disease Interactions
There are 3 disease interactions with posaconazole:
Azole antifungals (applies to posaconazole) QT prolongation
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Arrhythmias
Some azole antifungals have been associated with prolongation of the QT interval on the ECG. Rare cases of QT prolongation and torsade de pointes have been reported during postmarketing experience; such reports usually involved seriously ill patients with multiple confounding risk factors, such as structural heart disease, electrolyte abnormalities, and concomitant medications. These drugs should be administered with caution to patients with potentially proarrhythmic conditions. Concomitant use with other medications that have potential to increase the risk of cardiotoxicity should be avoided.
Posaconazole (applies to posaconazole) hepatotoxicity
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
The use of posaconazole has been associated with hepatic adverse reactions and hepatic toxicity. Liver function tests should be performed at the start of therapy and periodically in patients with preexisting hepatic abnormalities. Treatment should be withdrawn if persistent elevations or worsening of liver enzyme levels occur and clinical signs and symptoms consistent with liver disease develop.
Posaconazole (applies to posaconazole) renal dysfunction
Moderate Potential Hazard, Moderate plausibility.
Posaconazole injection should be avoided in patients with moderate to severe renal impairment (GRF <50 mL/min), unless an assessment of the risks and benefits justifies its use. If used, serum creatinine levels should be closely monitored. No dose adjustment is needed in patients with mild or moderate renal dysfunction using oral suspension. Patients with severe renal dysfunction should be closely monitored for breakthrough fungal infections due to a variability in exposure. Similar recommendations apply for posaconazole delayed-release tablets although specific studies have not been conducted.
Posaconazole drug interactions
There are 523 drug interactions with posaconazole
Posaconazole alcohol/food interactions
There is 1 alcohol/food interaction with posaconazole
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- Drug class: azole antifungals
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|