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Noxafil (posaconazole) Disease Interactions

There are 3 disease interactions with Noxafil (posaconazole):


Azole Antifungals (Includes Noxafil) ↔ Qt Prolongation

Moderate Potential Hazard, Moderate plausibility

Applies to: Arrhythmias

Most of the azole antifungals have been associated with prolongation of the QT interval. There have been postmarketing rare reports of QT prolongation, and torsade de pointes usually involving patients with risk factors such as structural heart disease, electrolyte abnormalities, and concomitant medications. These drugs should be administered with caution to patients with potentially proarrhythmic conditions. Concomitant use with other medications that have potential to increase the risk of cardiotoxicity should be avoided.


Posaconazole (Includes Noxafil) ↔ Hepatotoxicity

Moderate Potential Hazard, Moderate plausibility

Applies to: Liver Disease

The use of posaconazole has been associated with hepatic adverse reactions and hepatic toxicity. Liver function tests should be performed at the start of therapy and periodically in patients with preexisting hepatic abnormalities. Treatment should be withdrawn if persistent elevations or worsening of liver enzyme levels occur and clinical signs and symptoms consistent with liver disease develop.


Posaconazole (Includes Noxafil) ↔ Renal Dysfunction

Moderate Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction

Posaconazole injection should be avoided in patients with moderate to severe renal impairment (GRF <50 mL/min), unless an assessment of the risks and benefits justifies its use. If used, serum creatinine levels should be closely monitored. No dose adjustment is needed in patients with mild or moderate renal dysfunction using oral suspension. Patients with severe renal dysfunction should be closely monitored for breakthrough fungal infections due to a variability in exposure. Similar recommendations apply for posaconazole delayed-release tablets although specific studies have not been conducted.

Noxafil (posaconazole) drug Interactions

There are 640 drug interactions with Noxafil (posaconazole)

Noxafil (posaconazole) alcohol/food Interactions

There is 1 alcohol/food interaction with Noxafil (posaconazole)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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