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Orfadin (nitisinone) Disease Interactions

There is 1 disease interaction with Orfadin (nitisinone):


Nitisinone (applies to Orfadin) leukopenia/thrombocytopenia

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Neutropenia

In clinical trials, patients treated with oral formulations of nitisinone and dietary restriction developed transient leukopenia (3%), thrombocytopenia (3%), or both (1.5%). No patients developed infections or bleeding as a result of the episodes of leukopenia and thrombocytopenia. Caution is advised especially in patients with low blood cell counts. Platelet and white blood cell counts should be monitored during therapy with nitisinone.

Orfadin (nitisinone) drug interactions

There are 199 drug interactions with Orfadin (nitisinone)

Orfadin (nitisinone) alcohol/food interactions

There is 1 alcohol/food interaction with Orfadin (nitisinone)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.