Orfadin Disease Interactions
There is 1 disease interaction with Orfadin (nitisinone).
Nitisinone (applies to Orfadin) leukopenia/thrombocytopenia
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Neutropenia
In clinical trials, patients treated with oral formulations of nitisinone and dietary restriction developed transient leukopenia (3%), thrombocytopenia (3%), or both (1.5%). No patients developed infections or bleeding as a result of the episodes of leukopenia and thrombocytopenia. Caution is advised especially in patients with low blood cell counts. Platelet and white blood cell counts should be monitored during therapy with nitisinone.
References (1)
- (2002) "Product Information. Orfadin (nitisinone)." Orphan Medical
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Orfadin drug interactions
There are 244 drug interactions with Orfadin (nitisinone).
Orfadin alcohol/food interactions
There is 1 alcohol/food interaction with Orfadin (nitisinone).
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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