Skip to Content
Vaccines aren’t just for kids. Is your teen protected?

Micafungin Disease Interactions

There are 3 disease interactions with micafungin:

Moderate

Echinocandins (Includes Micafungin) ↔ Hepatotoxicity

Moderate Potential Hazard, Moderate plausibility

Applies to: Liver Disease

Laboratory abnormalities in liver function tests have been observed in healthy volunteers and patients treated with echinocandins, and clinical hepatic abnormalities have occurred in some patients with serious underlying conditions who were receiving multiple concomitant medications with echinocandin therapy. Isolated cases of significant hepatic dysfunction, hepatitis, or worsening hepatic failure have also been reported, although a causal relationship has not been established. Therapy with echinocandins should be administered cautiously in patients with preexisting liver disease. Liver function should be monitored regularly during therapy.

References

  1. "Product Information. Mycamine (micafungin)." Fujisawa, Deerfield, IL.
  2. "Product Information. Eraxis (anidulafungin)." Pfizer U.S. Pharmaceuticals Group, New York, NY.
  3. "Product Information. Cancidas (caspofungin)" Merck & Co, Inc, West Point, PA.
Moderate

Micafungin (Includes Micafungin) ↔ Anemia

Moderate Potential Hazard, Moderate plausibility

Applies to: Anemia

Acute, transient, and asymptomatic intravascular hemolysis and hemoglobinuria were reported in a healthy volunteer given an infusion of micafungin 200 mg and oral prednisolone 20 mg. Isolated cases of significant hemolysis and hemolytic anemia have also been reported in patients treated with micafungin. Therapy with micafungin should be administered cautiously in patients with preexisting anemia.

References

  1. "Product Information. Mycamine (micafungin)." Fujisawa, Deerfield, IL.
Moderate

Micafungin (Includes Micafungin) ↔ Renal Toxicity

Moderate Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction

Elevations in BUN and creatinine, as well as isolated cases of significant renal dysfunction or acute renal failure, have been reported in patients treated with micafungin. In controlled clinical trials, the incidence of drug-related renal adverse events was 0.4% for patients receiving micafungin and 0.5% for patients receiving fluconazole. Therapy with micafungin should be administered cautiously in patients with preexisting renal impairment. Renal function should be monitored regularly during therapy.

References

  1. "Product Information. Mycamine (micafungin)." Fujisawa, Deerfield, IL.

micafungin drug Interactions

There are 5 drug interactions with micafungin

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2016 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

Hide