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Namenda XR (memantine) Disease Interactions

There are 2 disease interactions with Namenda XR (memantine):

Moderate

Memantine (Includes Namenda XR) ↔ Hepatic Impairment

Moderate Potential Hazard, Moderate plausibility

Applies to: Liver Disease

Memantine should be used with caution in patients with severe hepatic impairment and a dosage reduction is recommended. No dosage adjustment is needed in patients with mild or moderate hepatic impairment.

Moderate

Memantine (Includes Namenda XR) ↔ Renal Impairment

Moderate Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction, Urinary Tract Infection

Memantine renal clearance involves active tubular secretion moderated by pH dependent tubular reabsorption and conditions that raise urine pH may increase the plasma levels of memantine. Therapy with memantine should be used cautiously in patients with conditions that raise urine pH, such as renal tubular acidosis or severe infections of the urinary tract. Additionally, memantine should be used with caution in patients with severe renal impairment and a dosage reduction is recommended. No dosage adjustment is needed in patients with mild or moderate renal impairment.

Namenda XR (memantine) drug Interactions

There are 175 drug interactions with Namenda XR (memantine)

Namenda XR (memantine) alcohol/food Interactions

There is 1 alcohol/food interaction with Namenda XR (memantine)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

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