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Emverm (mebendazole) Disease Interactions

There is 1 disease interaction with Emverm (mebendazole):


Mebendazole (Includes Emverm) ↔ Liver Disease

Moderate Potential Hazard, Low plausibility

Applies to: Liver Disease

Although mebendazole is poorly absorbed from the gastrointestinal tract (only 2% to 10% of a dose is absorbed systemically), absorbed drug is primarily metabolized by the liver. Therapy with mebendazole should be administered cautiously in patients with liver disease. Liver function tests should be monitored during extended use or high-dose therapy, since elevation of serum transaminases (AST, ALT) and GGT, as well as rare cases of hepatitis, have been reported during prolonged therapy and at dosages substantially above those normally recommended.


  1. Bekhti A, Pirotte J "Hepatotoxicity of mebendazole: relationship with serum concentrations of the drug." Gastroenterol Clin Biol 11 (1987): 701-3
  2. Witassek F, Bircher "Chemotherapy of larval echinococcosis with mebendazole: microsomal liver function and cholestasis as determinants of plasma drug level." Eur J Clin Pharmacol 25 (1983): 85-90
  3. "Product Information. Vermox (mebendazole)." Janssen Pharmaceutica, Titusville, NJ.

Emverm (mebendazole) drug Interactions

There are 11 drug interactions with Emverm (mebendazole)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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