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Sulfamag (magnesium sulfate) Disease Interactions

There are 4 disease interactions with Sulfamag (magnesium sulfate):


anticonvulsants (Includes Sulfamag) ↔ depression

Severe Potential Hazard, Moderate plausibility

Applies to: Depression

Antiepileptic drugs can increase depression and suicidal thoughts or behaviors in patients receiving these drugs for any indication. Patients should be monitored for the emergence or worsening of depression, suicidal thoughts and unusual changes in mood or behavior. Caregivers and family should be alert for the emergence or worsening of symptoms. Behaviors of concern should be reported immediately to the healthcare providers.


magnesium IV (Includes Sulfamag) ↔ cardiac disease

Severe Potential Hazard, High plausibility

Applies to: Myocardial Infarction, Heart Block

The parenteral administration of magnesium is contraindicated in patients with heart block or heart damage from myocardial infarction. These conditions may be exacerbated during magnesium infusion. High serum levels of magnesium (> 4.5 mEq/L) can cause sinus bradycardia, AV block, nodal rhythms, and bundle branch block, which can progress to asystole and cardiac arrest at magnesium levels of approximately 14 mEq/L to 15 mEq/L. If parenteral magnesium is used in patients with preexisting conduction disturbances, it should be infused at a slower rate, and cardiac function and serum magnesium level should be closely monitored. The usual precautionary measures should be observed to prevent hypermagnesemia, and IV calcium salts (e.g., calcium gluconate), pressors, cardiac pacemakers, and equipment for supportive care should be immediately available in case of acute magnesium intoxication.


  1. Viskin S, Belhassen B, Laniado S "Deterioration of ventricular tachycardia to ventricular fibrillation after rapid intravenous administration of magnesium sulfate." Chest 101 (1992): 1445-7
  2. "Product Information. Magnesium Sulfate (magnesium sulfate)." Abbott Pharmaceutical, Abbott Park, IL.
  3. Sherer DM, Cialone PR, Abramowicz JS, Woods JR Jr "Transient symptomatic subendocardial ischemia during intravenous magnesium sulfate tocolytic therapy." Am J Obstet Gynecol 166 (1992): 33-5

magnesium IV (Includes Sulfamag) ↔ pregnancy

Severe Potential Hazard, Moderate plausibility

Applies to: Pre-eclampsia/Eclampsia

Intravenous magnesium should not be given to mothers with preeclampsia during the two hours preceding delivery.


magnesium salts (Includes Sulfamag) ↔ renal dysfunction

Severe Potential Hazard, High plausibility

Applies to: Renal Dysfunction

Magnesium is eliminated by the kidney. The serum concentration of magnesium is increased in patients with renal impairment. Magnesium toxicity includes CNS depression, muscular paralysis, respiratory depression, hypotension and prolonged cardiac conduction time. Disappearance of the patellar reflex is a useful clinical sign of magnesium intoxication. Therapy with magnesium should be administered cautiously and dosages should be modified in patients with compromised renal function. Clinical monitoring of serum magnesium levels is recommended.


  1. "Product Information. Mag-Ox 400 (magnesium oxide)." Blaine, Erlanger, KY.
  2. "Product Information. Losospan (magaldrate)." Whitehall-Robbins, Madison, NJ.
  3. "Product Information. Slow-Mag (magnesium chloride)." Searle, Skokie, IL.
  4. "Product Information. Magonate (magnesium gluconate)." Fleming and Company, Fenton, MO.
  5. "Product Information. Uro-Mag (magnesium oxide)." Blaine, Erlanger, KY.
View all 5 references

Sulfamag (magnesium sulfate) drug Interactions

There are 343 drug interactions with Sulfamag (magnesium sulfate)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.