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Magaldrate Plus Suspension Disease Interactions

There are 3 disease interactions with Magaldrate Plus Suspension (magaldrate / simethicone).

Major

Aluminum-containing antacids (applies to Magaldrate Plus Suspension) constipation

Major Potential Hazard, High plausibility. Applicable conditions: Renal Dysfunction, Intestinal Obstruction, Phosphate Imbalance

Aluminum containing antacids may produce constipation, which may lead to intestinal obstruction. Osteomalacia and hypophosphatemia may be produced in patients with renal dysfunction who are not receiving dialysis. Patients with renal dysfunction, intestinal obstruction, osteomalacia, or hypophosphatemia should use antacids with low or no aluminum content.

References

  1. "Product Information. Amphojel (aluminum hydroxide)." Wyeth-Ayerst Laboratories PROD (2001):
  2. "Product Information. Rolaids (dihydroxyaluminum sodium carbonate)." Warner Lambert Consumer Healthcare PROD (2001):
  3. "Product Information. Losospan (magaldrate)." Whitehall-Robbins PROD (2001):
Major

Magnesium salts (applies to Magaldrate Plus Suspension) renal dysfunction

Major Potential Hazard, High plausibility.

Magnesium is eliminated by the kidney. The serum concentration of magnesium is increased in patients with renal impairment. Magnesium toxicity includes CNS depression, muscular paralysis, respiratory depression, hypotension and prolonged cardiac conduction time. Disappearance of the patellar reflex is a useful clinical sign of magnesium intoxication. Therapy with magnesium should be administered cautiously and dosages should be modified in patients with compromised renal function. Clinical monitoring of serum magnesium levels is recommended.

References

  1. "Product Information. Mag-Ox 400 (magnesium oxide)." Blaine Company Inc. PROD (2001):
  2. "Product Information. Uro-Mag (magnesium oxide)." Blaine Company Inc. PROD (2001):
  3. "Product Information. Slow-Mag (magnesium chloride)." Searle PROD (2001):
  4. "Product Information. Magonate (magnesium gluconate)." Fleming and Company PROD (2001):
  5. "Product Information. Losospan (magaldrate)." Whitehall-Robbins PROD (2001):
View all 5 references
Moderate

Magnesium-containing antacids (applies to Magaldrate Plus Suspension) diarrhea

Moderate Potential Hazard, Moderate plausibility.

The use of magnesium-containing antacids has been associated with a laxative effect and may cause diarrhea. Therapy with magnesium-containing antacids should be administered cautiously in patients with diarrhea.

References

  1. "Product Information. Losospan (magaldrate)." Whitehall-Robbins PROD (2001):

Magaldrate Plus Suspension drug interactions

There are 221 drug interactions with Magaldrate Plus Suspension (magaldrate / simethicone).

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More about Magaldrate Plus Suspension (magaldrate / simethicone)

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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