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Levoleucovorin Disease Interactions

There is 1 disease interaction with levoleucovorin:


Levoleucovorin (applies to levoleucovorin) seizures

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Syncope

Levoleucovorin is the levo isomeric form of racemic d,l-leucovorin, present as the calcium salt. Seizures and/or syncope have been reported rarely in cancer patients receiving d,l-leucovorin, usually in association with fluoropyrimidine administration, and most commonly in those with CNS metastases or other predisposing factors. Care is recommended when using this agent in patient with seizure disorders or at risk of seizures even though a causal relationship has not been established.

Levoleucovorin drug interactions

There are 24 drug interactions with levoleucovorin

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.