Levoleucovorin Disease Interactions
There is 1 disease interaction with levoleucovorin.
Levoleucovorin (applies to levoleucovorin) seizures
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Syncope
Levoleucovorin is the levo isomeric form of racemic d,l-leucovorin, present as the calcium salt. Seizures and/or syncope have been reported rarely in cancer patients receiving d,l-leucovorin, usually in association with fluoropyrimidine administration, and most commonly in those with CNS metastases or other predisposing factors. Care is recommended when using this agent in patient with seizure disorders or at risk of seizures even though a causal relationship has not been established.
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Levoleucovorin drug interactions
There are 25 drug interactions with levoleucovorin.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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