Lenalidomide Disease Interactions
There are 3 disease interactions with lenalidomide:
Lenalidomide (Includes lenalidomide) ↔ renal impairment
Moderate Potential Hazard, Moderate plausibility. Applies to: Renal Dysfunction
Lenalidomide is primarily excreted unchanged by the kidney. Adjustments to the starting dose are recommended in patients with moderate (CrCl 30-60 mL/min) or severe renal impairment (<30 mL/min), and in patients on dialysis.
Lenalidomide (Includes lenalidomide) ↔ thromboembolic events
Moderate Potential Hazard, Moderate plausibility. Applies to: History - Thrombotic/Thromboembolic Disorder, Pulmonary Embolism
Venous thromboembolic events (deep venous thrombosis and pulmonary embolism) and arterial thromboses are increased in patients using lenalidomide. Patients with known risk factors such as prior thrombosis, may be at greater risk and actions should be taken to minimize all other modifiable risk factors (e.g., smoking, hyperlipidemia, hypertension).
Miscellaneous antineoplastics (Includes lenalidomide) ↔ anemia
Moderate Potential Hazard, Moderate plausibility. Applies to: Anemia, Neutropenia, Thrombocytopenia
Some miscellaneous antineoplastics such as azacitidine and lenalidomide cause anemia, neutropenia, and thrombocytopenia. Patients with these preexisting conditions should be monitored carefully. Monitor complete blood counts frequently for response and/or toxicity, at a minimum, prior to each dosing cycle.
Lenalidomide drug interactions
There are 225 drug interactions with lenalidomide
More about lenalidomide
- Lenalidomide Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- 10 Reviews
- Drug class: miscellaneous antineoplastics
- FDA Alerts (1)
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
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