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Lazertinib Disease Interactions

There are 4 disease interactions with lazertinib.

Moderate

Lazertinib (applies to lazertinib) ILD/pneumonitis

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Interstitial Pneumonitis

Lazertinib, which is administered in combination with amivantamab, can cause interstitial lung disease (ILD)/pneumonitis. Patients should be monitored for worsening or new symptoms indicative of ILD/pneumonitis, such as dyspnea, cough or fever.

Moderate

Lazertinib (applies to lazertinib) liver dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Lazertinib has not been studied in patients with severe hepatic impairment (total bilirubin greater than 3 x upper limit of normal and any AST).

Moderate

Lazertinib (applies to lazertinib) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

Lazertinib has not been studied in patients with severe renal dysfunction or end-stage renal disease (eGFR less than 30 mL/min).

Moderate

Lazertinib (applies to lazertinib) vision disturbances

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Visual Defect/Disturbance

Lazertinib, which is administered in combination with amivantamab, can cause ocular toxicity, including keratitis. Patients should be monitored for new or worsening eye symptoms and referred promptly to an ophthalmologist.

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Lazertinib drug interactions

There are 376 drug interactions with lazertinib.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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