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Lactulose Disease Interactions

There are 4 disease interactions with lactulose.

Major

Lactulose (applies to lactulose) galactosemia

Major Potential Hazard, High plausibility.

Since lactulose solution contains galactose, use is contraindicated in patients who require a low galactose diet.

References

  1. "Product Information. Chronulac (lactulose)." Hoechst Marion Roussel PROD (2002):
  2. "Product Information. Cephulac (lactulose)." Hoechst Marion Roussel PROD (2002):
  3. "Product Information. Duphalac (lactulose)." Solvay Pharmaceuticals Inc PROD (2001):
  4. "Product Information. Enulose (lactulose)." United Research Laboratories/Mutual Pharmaceutical Company (2012):
View all 4 references
Major

Laxatives (applies to lactulose) inflammatory bowel disease

Major Potential Hazard, Moderate plausibility.

The use of laxatives is contraindicated in patients with inflammatory bowel disease. Patients with inflammatory bowel disease may experience colonic perforation with use of stimulant laxatives.

References

  1. "Product Information. Dulcolax (bisacodyl)." Ciba Self-Medication Inc PROD (2001):
  2. "Product Information. Fleet Bisacodyl (bisacodyl)." Fleet PROD
  3. "Product Information. Kondremul Plain (mineral oil)." Bristol-Myers Squibb PROD
  4. "Product Information. Neoloid (castor oil)." Paddock Laboratories Inc PROD (2001):
  5. "Product Information. SenoSol-X (senna)." Apothecon Inc (2022):
  6. "Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates)." Braintree Laboratories (2010):
View all 6 references
Major

Laxatives (applies to lactulose) intestinal obstruction disorders

Major Potential Hazard, Moderate plausibility. Applicable conditions: Gastrointestinal Obstruction

The use of laxatives is contraindicated in patients with intestinal obstruction disorders. Patients with intestinal obstruction disorders may need their underlying condition treated to correct the constipation. Some laxatives require reduction in the colon to their active form to be effective which may be a problem in patients with intestinal obstruction.

References

  1. "Product Information. Dulcolax (bisacodyl)." Ciba Self-Medication Inc PROD (2001):
  2. "Product Information. Fleet Bisacodyl (bisacodyl)." Fleet PROD
  3. "Product Information. Kondremul Plain (mineral oil)." Bristol-Myers Squibb PROD
  4. "Product Information. Fleet Mineral Oil Enema (mineral oil)." Fleet PROD (2001):
  5. "Product Information. Citrucel (methylcellulose)." SmithKline Beecham PROD (2001):
  6. "Product Information. Fleet Babylax (glycerin)." Alcon Laboratories Inc PROD (2001):
  7. "Product Information. SenoSol-X (senna)." Apothecon Inc (2022):
  8. "Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates)." Braintree Laboratories (2010):
View all 8 references
Moderate

Lactulose (applies to lactulose) diabetes

Moderate Potential Hazard, High plausibility. Applicable conditions: Diabetes Mellitus

Since lactulose solution contains galactose and lactose, it should be used cautiously in patients with diabetes.

References

  1. "Product Information. Chronulac (lactulose)." Hoechst Marion Roussel PROD (2002):
  2. "Product Information. Cephulac (lactulose)." Hoechst Marion Roussel PROD (2002):
  3. "Product Information. Duphalac (lactulose)." Solvay Pharmaceuticals Inc PROD (2001):
  4. "Product Information. Enulose (lactulose)." United Research Laboratories/Mutual Pharmaceutical Company (2012):
View all 4 references

Lactulose drug interactions

There are 246 drug interactions with lactulose.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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