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Cresemba (isavuconazonium) Disease Interactions

There are 2 disease interactions with Cresemba (isavuconazonium):

Major

Isavuconazonium (Includes Cresemba) ↔ Short Qt

Severe Potential Hazard, Moderate plausibility

Applies to: Short QT Syndrome

Isavuconazonium has shown to shorten the QTc interval in a concentration- related manner. The use of this drug is contraindicated in patients with familial short QT syndrome.

Moderate

Isavuconazonium (Includes Cresemba) ↔ Liver Disease

Moderate Potential Hazard, Moderate plausibility

Applies to: Liver Disease

The use of isavuconazonium has been associated with hepatic adverse reactions. Liver function tests should be performed at the start of therapy and periodically in patients with preexisting hepatic abnormalities. Treatment should be withdrawn if persistent elevations or worsening of liver enzyme levels occur. Isavuconazonium has not been studies in patients with severe hepatic impairment (Child-Pugh Class C) and should be used in these patients only when the benefits outweigh the risk.

Cresemba (isavuconazonium) drug Interactions

There are 448 drug interactions with Cresemba (isavuconazonium)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

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