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Ezfe (iron polysaccharide) Disease Interactions

There are 3 disease interactions with Ezfe (iron polysaccharide):


Ferrous salts (applies to Ezfe) hemoglobin abnormalities

Major Potential Hazard, High plausibility. Applicable conditions: Blood Transfusion, Hemoglobinopathy

There is no excretory mechanism for iron. Iron will correct only hemoglobin abnormalities due to iron deficiency and should not be used to treat conditions such as thalassemia, hemosiderosis, hemochromatosis, normocytic anemia (unless iron deficiency exists), or in patients receiving blood transfusions. Clinical monitoring of erythropoietic function and ferritin levels is recommended.


  1. "Product Information. INFeD (iron dextran)." Schein Pharmaceuticals Inc, Florham Park, NJ.

Ferrous salts (applies to Ezfe) achlorhydria

Moderate Potential Hazard, Moderate plausibility.

Gastric acidity increases iron bioavailability by maintaining the ingested iron in a reduced form as ferrous ions, which are more readily absorbed than ferric ions. Therefore, when iron therapy is administered orally, higher dosages may be necessary for patients with decreased gastric acid production. Also, a liquid formulation is recommended in these patients because dissolution of the tablet coating depends on normal gastric acidity.


  1. "Product Information. Feosol Tablets (ferrous sulfate)." SmithKline Beecham, Philadelphia, PA.

Ferrous salts (applies to Ezfe) gastrointestinal irritation

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Peptic Ulcer, Colitis/Enteritis (Noninfectious)

Iron can be irritating and damaging to gastrointestinal mucosa. Iron therapy should be administered cautiously in patients with peptic ulcer disease, enteritis, or ulcerative colitis.


  1. "Product Information. Feosol Tablets (ferrous sulfate)." SmithKline Beecham, Philadelphia, PA.

Ezfe (iron polysaccharide) drug interactions

There are 84 drug interactions with Ezfe (iron polysaccharide)

Ezfe (iron polysaccharide) alcohol/food interactions

There is 1 alcohol/food interaction with Ezfe (iron polysaccharide)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.