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Iobenguane I 123 Disease Interactions

There are 3 disease interactions with iobenguane I 123.

Moderate

Iobenguane I-123 (applies to iobenguane I 123) hypertension

Moderate Potential Hazard, Moderate plausibility.

Iobenguane I-123 may increase release of norepinephrine from chromaffin granules and produce a transient episode of hypertension. It is recommended to assess the patient's pulse and blood pressure before and intermittently for 30 minutes after iobenguane I-123 administration. Care should be exercised when using this agent in patients with hypertension. Prior to Iobenguane I-123 administration, ensure emergency cardiac and anti-hypertensive treatments are readily available.

Moderate

Iobenguane I-123 (applies to iobenguane I 123) parkinson's disease

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Parkinsonism

Individuals with conditions that affect the sympathetic nervous system, e.g., Parkinsonian syndromes such as Parkinson's disease or multiple system atrophy, may show decreased cardiac uptake of iobenguane I-123 independent of heart disease.

Moderate

Iobenguane I-123 (applies to iobenguane I 123) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Iobenguane I-123 is cleared by the kidneys and is not dialyzable. When iobenguane I-123 is used in patients with severe renal impairment, the radiation dose may be increased due to delayed elimination of the drug which may also reduce the target to background rations and decrease the quality of scintigraphic images. Care should be exercised when using this agent in patients with severe renal impairment as the safety and efficacy have not been established in these patients. It is recommended to consider assessment of renal function in patients prior to iobenguane I-123 administration.

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Iobenguane I 123 drug interactions

There are 91 drug interactions with iobenguane I 123.

Iobenguane I 123 alcohol/food interactions

There is 1 alcohol/food interaction with iobenguane I 123.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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