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Ganite (gallium nitrate) Disease Interactions

There are 2 disease interactions with Ganite (gallium nitrate):

Major

Gallium nitrate (applies to Ganite) renal dysfunction

Major Potential Hazard, High plausibility.

The use of gallium nitrate is contraindicated in patients with severe renal impairment (serum creatinine > 2.5 mg/dL). Elevations in serum creatinine and/or BUN have occurred in approximately 12% of patients treated for hypercalcemia of malignancy. Rare cases of acute renal failure have also been reported, although a causal relationship to the drug was not established. In patients with less severe renal impairment, therapy with gallium nitrate should be administered cautiously, since further depression of renal function may occur. Renal status should be closely monitored, and care taken to ensure adequate hydration and urinary output (2 L/day is recommended) both before and during treatment. Therapy should be discontinued if serum creatinine exceeds 2.5 mg/dL.

References

  1. "Product Information. Ganite (gallium nitrate)." Fujisawa, Deerfield, IL.
Moderate

Gallium nitrate (applies to Ganite) hypocalcemia

Moderate Potential Hazard, High plausibility.

Gallium nitrate inhibits calcium resorption from bone and is used to treat symptomatic hypercalcemia of malignancy. Mild to moderate hypocalcemia occurred in approximately 38% of treated patients in one clinical trial. Gallium nitrate should generally not be used in patients with preexisting hypocalcemia. If hypocalcemia occurs during treatment, gallium nitrate should be stopped. Short-term calcium therapy may be necessary to reverse the condition.

References

  1. "Product Information. Ganite (gallium nitrate)." Fujisawa, Deerfield, IL.

Ganite (gallium nitrate) drug interactions

There are 58 drug interactions with Ganite (gallium nitrate)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.