Ganite Disease Interactions
There are 2 disease interactions with Ganite (gallium nitrate).
Gallium nitrate (applies to Ganite) renal dysfunction
Major Potential Hazard, High plausibility.
The use of gallium nitrate is contraindicated in patients with severe renal impairment (serum creatinine > 2.5 mg/dL). Elevations in serum creatinine and/or BUN have occurred in approximately 12% of patients treated for hypercalcemia of malignancy. Rare cases of acute renal failure have also been reported, although a causal relationship to the drug was not established. In patients with less severe renal impairment, therapy with gallium nitrate should be administered cautiously, since further depression of renal function may occur. Renal status should be closely monitored, and care taken to ensure adequate hydration and urinary output (2 L/day is recommended) both before and during treatment. Therapy should be discontinued if serum creatinine exceeds 2.5 mg/dL.
Gallium nitrate (applies to Ganite) hypocalcemia
Moderate Potential Hazard, High plausibility.
Gallium nitrate inhibits calcium resorption from bone and is used to treat symptomatic hypercalcemia of malignancy. Mild to moderate hypocalcemia occurred in approximately 38% of treated patients in one clinical trial. Gallium nitrate should generally not be used in patients with preexisting hypocalcemia. If hypocalcemia occurs during treatment, gallium nitrate should be stopped. Short-term calcium therapy may be necessary to reverse the condition.
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Ganite drug interactions
There are 65 drug interactions with Ganite (gallium nitrate).
More about Ganite (gallium nitrate)
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- Drug class: miscellaneous bone resorption inhibitors
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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Further information
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