Horizant (gabapentin enacarbil) Disease Interactions
There are 3 disease interactions with Horizant (gabapentin enacarbil):
Gabapentin (Includes Horizant) ↔ Renal Dysfunction
Severe Potential Hazard, High plausibility
Applies to: Renal Dysfunction
Gabapentin is primarily eliminated unchanged by the kidney. Therapy with gabapentin should be administered cautiously in patients with impaired renal function. Dosage adjustments and titration should be made in accordance with product package labeling and individual patient response.
- Vollmer KO, von Hodenberg A, Kolle EU "Pharmacokinetics and metabolism of gabapentin in rat, dog and man." Arzneimittelforschung 36 (1986): 830-9
- Mclean MJ "Clinical pharmacokinetics of gabapentin." Neurology 44 (1994): 17-22
- Blum RA, Comstock TJ, Sica DA, Schultz RW, Keller E, Reetze P, Bockbrader H, Tuerck D, Busch JA, Reece PA, et al "Pharmacokinetics of gabapentin in subjects with various degrees of renal function." Clin Pharmacol Ther 56 (1994): 154-9
Antiepileptics (Includes Horizant) ↔ Suicidal Tendency
Moderate Potential Hazard, Moderate plausibility
Applies to: Depression, Psychosis
Antiepileptic drugs (AEDs) have been associated with an increased risk of suicidal thoughts or behavior in patients taking these drugs for any indication. Pooled analyses of 199 placebo-controlled clinical studies involving the use of 11 different AEDs across multiple indications in either monotherapy or adjunctive therapy for a median treatment duration of 12 weeks (up to a maximum of 24 weeks) showed that patients receiving AEDs had approximately twice the risk of suicidal thinking or behavior compared to patients receiving placebo. The estimated rate of suicidal behavior or ideation among 27,863 AED-treated patients was 0.43%, compared to 0.24% for 16,029 placebo-treated patients, representing an increase of approximately one case for every 530 patients treated. There were four suicides in AED-treated patients and none in placebo-treated patients, although the number is too small to establish any causal relationship. The increased risk of suicidal thoughts or behavior was observed as early as one week after starting AEDs and persisted for the duration of treatment assessed. The risk did not vary substantially by age (5 to 100 years) in the clinical trials analyzed. Therapy with AEDs should be administered cautiously in patients with depression or other psychiatric disorders. The risk of suicidal thoughts and behavior should be carefully assessed against the risk of untreated illness, bearing in mind that epilepsy and many other conditions for which AEDs are prescribed are themselves associated with morbidity and mortality and an increased risk of suicidal thoughts and behavior. Patients, caregivers, and families should be alert to the emergence or worsening of signs and symptoms of depression, any unusual changes in mood or behavior, or the emergence of suicidal thoughts or behavior. For clinically significant or persistent symptoms, a dosage reduction or treatment withdrawal should be considered. If patients have symptoms of suicidal ideation or behavior, treatment should be discontinued.
Gabapentin (Includes Horizant) ↔ Hemodialysis
Moderate Potential Hazard, High plausibility
Applies to: hemodialysis
Gabapentin is removed by hemodialysis and should be administered after dialysis.
- "Product Information. Neurontin (gabapentin)." Parke-Davis, Morris Plains, NJ.
- Wong MO, Eldon MA, Keane WF, Turck D, Bockbrader HN, Underwood BA, Sedman AJ, Halstenson CE "Disposition of gabapentin in anuric subjects on hemodialysis." J Clin Pharmacol 35 (1995): 622-6
Horizant (gabapentin enacarbil) drug Interactions
There are 564 drug interactions with Horizant (gabapentin enacarbil)
Horizant (gabapentin enacarbil) alcohol/food Interactions
There is 1 alcohol/food interaction with Horizant (gabapentin enacarbil)
Drug Interaction Classification
Do not stop taking any medications without consulting your healthcare provider.