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Flucytosine Disease Interactions

There are 4 disease interactions with flucytosine.

Major

Flucytosine (applies to flucytosine) myelosuppression

Major Potential Hazard, High plausibility. Applicable conditions: Bone Marrow Depression/Low Blood Counts, Immunodeficiency

Flucytosine may frequently cause bone marrow toxicity, which can be irreversible and fatal in immunosuppressed patients. Flucytosine should be used with extreme caution in patients with preexisting bone marrow suppression. Frequent blood counts are recommended.

Major

Flucytosine (applies to flucytosine) renal dysfunction

Major Potential Hazard, High plausibility.

Flucytosine must be given with extreme caution to patients with impaired renal function. Flucytosine is excreted primarily by the kidneys, and renal impairment may lead to accumulation of the drug. Serum concentrations of the drug should be monitored to determine the adequacy of renal excretion in such patients. Dosage adjustments should be made in patients with renal insufficiency to prevent progressive accumulation of active drug. Close monitoring of renal, hematologic and hepatic function in all patients is recommended.

Moderate

Flucytosine (applies to flucytosine) hemodialysis

Moderate Potential Hazard, High plausibility.

Flucytosine is substantially removed by hemodialysis and should be administered after dialysis.

Moderate

Flucytosine (applies to flucytosine) hypokalemia

Moderate Potential Hazard, Moderate plausibility.

Flucytosine may cause hypokalemia. Patients with preexisting hypokalemia should be monitored closely for worsening electrolyte disturbances during therapy with flucytosine.

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Flucytosine drug interactions

There are 114 drug interactions with flucytosine.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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