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Floxuridine Disease Interactions

There are 6 disease interactions with floxuridine:

Major

Floxuridine (applies to floxuridine) dihydropyrimidine deficiency

Major Potential Hazard, High plausibility. Applicable conditions: Enzymopathy (Unspecified)

An inherited deficiency of dihydropyrimidine can alter the clearance of 5- FU and result in severe toxicity such as stomatitis, diarrhea, neutropenia and neurotoxicity. When administered as a continuous intra-arterial infusion, floxuridine (FUDR) is metabolized to FDUMP. However, with rapid intra-arterial injection, FUDR is metabolized to 5-FU. 5-FU requires metabolized to an inactive form by dihydropyrimidine dehydrogenase. FUDR should not be administered by rapid intra-arterial infusion to patients with dihydropyrimidine deficiency.

References

  1. "Product Information. FUDR Sterile (floxuridine)." Roche Laboratories, Nutley, NJ.
Major

Floxuridine (applies to floxuridine) infections

Major Potential Hazard, High plausibility. Applicable conditions: Infection - Bacterial/Fungal/Protozoal/Viral

The use of floxuridine (FUDR) is contraindicated in patients with potentially serious infectious diseases. FUDR can induce myelosuppression. All patients should be instructed to immediately report any signs or symptoms suggesting infection such as fever, sore throat, or local infection during therapy with FUDR. Close clinical monitoring of hematopoietic function is recommended.

References

  1. "Product Information. FUDR Sterile (floxuridine)." Roche Laboratories, Nutley, NJ.
Major

Floxuridine (applies to floxuridine) malnutrition

Major Potential Hazard, Moderate plausibility. Applicable conditions: Cachexia

Floxuridine therapy is contraindicated for patients in a poor nutritional state.

Major

Floxuridine (applies to floxuridine) myelosuppression

Major Potential Hazard, High plausibility. Applicable conditions: Bone Marrow Depression/Low Blood Counts, Fever

The use of floxuridine (FUDR) is contraindicated in patients with bone marrow suppression. FUDR induces myelosuppression at recommended dosages. Therapy with FUDR should be administered cautiously in patients who have had prior high-dose pelvic irradiation or alkylating agents or who have widespread metastatic tumor involvement of the bone marrow. Patients should be instructed to immediately report any signs or symptoms suggesting bone marrow suppression such as fever, sore throat, local infection, or bleeding. Close clinical monitoring of hematopoietic function is recommended and therapy should be withheld if platelet counts falls below 100,000/mm3 and/or white blood cell (WBC) counts falls below 3500/mm3 or a rapid fall in WBC is noted.

References

  1. "Product Information. FUDR Sterile (floxuridine)." Roche Laboratories, Nutley, NJ.
Major

Floxuridine (applies to floxuridine) stomatitis

Major Potential Hazard, Moderate plausibility. Applicable conditions: Peptic Ulcer, Inflammatory Bowel Disease

Floxuridine induces stomatitis within the gastrointestinal tract. Therapy with floxuridine should be administered with extreme caution in patients with peptic ulcer disease and ulcerative colitis.

References

  1. "Product Information. FUDR Sterile (floxuridine)." Roche Laboratories, Nutley, NJ.
Moderate

Floxuridine (applies to floxuridine) bleeding disorders

Moderate Potential Hazard, Moderate plausibility.

Floxuridine (FUDR) induces myelosuppression. Therapy with FUDR should be administered cautiously in patients with bleeding tendencies. Therapy with FUDR should be promptly discontinued following bleeding from any sight. Patients should be instructed to immediately report any signs or symptoms suggesting bleeding such as petechiae, purpura, hematuria, or melena. Close clinical monitoring of hematopoietic function is recommended. Therapy with FUDR should be withheld if platelet counts falls below 100,000/mm3.

References

  1. "Product Information. FUDR Sterile (floxuridine)." Roche Laboratories, Nutley, NJ.

Floxuridine drug interactions

There are 193 drug interactions with floxuridine

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.