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Ferrous sulfate Disease Interactions

There are 3 disease interactions with ferrous sulfate:


Ferrous salts (Includes ferrous sulfate) ↔ hemoglobin abnormalities

Severe Potential Hazard, High plausibility. Applies to: Hemoglobinopathy, Blood Transfusion

There is no excretory mechanism for iron. Iron will correct only hemoglobin abnormalities due to iron deficiency and should not be used to treat conditions such as thalassemia, hemosiderosis, hemochromatosis, normocytic anemia (unless iron deficiency exists), or in patients receiving blood transfusions. Clinical monitoring of erythropoietic function and ferritin levels is recommended.


  1. "Product Information. INFeD (iron dextran)." Schein Pharmaceuticals Inc, Florham Park, NJ.

Ferrous salts (Includes ferrous sulfate) ↔ achlorhydria

Moderate Potential Hazard, Moderate plausibility. Applies to: Achlorhydria

Gastric acidity increases iron bioavailability by maintaining the ingested iron in a reduced form as ferrous ions, which are more readily absorbed than ferric ions. Therefore, when iron therapy is administered orally, higher dosages may be necessary for patients with decreased gastric acid production. Also, a liquid formulation is recommended in these patients because dissolution of the tablet coating depends on normal gastric acidity.


  1. "Product Information. Feosol Tablets (ferrous sulfate)." SmithKline Beecham, Philadelphia, PA.

Ferrous salts (Includes ferrous sulfate) ↔ gastrointestinal irritation

Moderate Potential Hazard, High plausibility. Applies to: Colitis/Enteritis (Noninfectious), Peptic Ulcer

Iron can be irritating and damaging to gastrointestinal mucosa. Iron therapy should be administered cautiously in patients with peptic ulcer disease, enteritis, or ulcerative colitis.


  1. "Product Information. Feosol Tablets (ferrous sulfate)." SmithKline Beecham, Philadelphia, PA.

Ferrous sulfate drug interactions

There are 158 drug interactions with ferrous sulfate

Ferrous sulfate alcohol/food interactions

There is 1 alcohol/food interaction with ferrous sulfate

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.