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Edetate disodium (edta) Disease Interactions

There are 5 disease interactions with edetate disodium (edta).

Major

Disodium EDTA (applies to edetate disodium (edta)) cardiovascular dysfunction

Major Potential Hazard, High plausibility. Applicable conditions: Arrhythmias, Congestive Heart Failure, Hypokalemia

Severe cardiac arrhythmias associated with EDTA disodium are due to decreased serum calcium. EDTA also exerts a negative inotropic effect on the heart and can exacerbate congestive heart failure. EDTA disodium functions to reduce serum concentrations of calcium by forming stable soluble complexes with calcium. EDTA also chelates zinc, magnesium, and other trace metals and increases potassium excretion in the urine. Therapy with EDTA disodium should be used with caution in patients with limited cardiac reserve, congestive heart failure or arrhythmia. Clinical monitoring of cardiac function and electrolytes (including calcium, potassium, and magnesium) is recommended.

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Major

Disodium EDTA (applies to edetate disodium (edta)) renal dysfunction

Major Potential Hazard, High plausibility.

The use of disodium EDTA is contraindicated in patients with anuria and severe renal dysfunction. Dose-related nephrotoxicity (usually reversible) associated with EDTA has included polyuria, dysuria, oliguria, proteinuria, cast and cells in urine, renal insufficiency/failure, and rarely, acute tubular necrosis. EDTA disodium is eliminated by the kidney primarily chelated to calcium. Impaired renal function decreases the elimination of EDTA and may increase its nephrotoxicity.

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Major

Disodium EDTA (applies to edetate disodium (edta)) tuberculosis

Major Potential Hazard, High plausibility. Applicable conditions: Tuberculosis -- Active

The use of EDTA disodium is usually contraindicated in patients with active tuberculosis or healed calcified tubercular lesions. EDTA disodium forms stable soluble complexes with calcium.

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Moderate

Disodium EDTA (applies to edetate disodium (edta)) seizures

Moderate Potential Hazard, Moderate plausibility.

EDTA disodium functions to reduce serum calcium concentrations by forming stable soluble complexes with calcium. Hypocalcemia may precipitate seizures. Therapy with EDTA disodium should be used with caution in patients with intracranial lesions or with or predisposed to seizure disorders. Clinical monitoring of electrolyte concentrations is recommended.

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Moderate

EDTA (applies to edetate disodium (edta)) insulin/diabetes

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Diabetes Mellitus

EDTA may chelate zinc present in exogenous insulin and alter glucose concentrations and insulin requirements in patients with diabetes. Insulin dosages may need to be adjusted in diabetic patients administered EDTA.

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Edetate disodium (edta) drug interactions

There are 26 drug interactions with edetate disodium (edta).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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