Northera (droxidopa) Disease Interactions
There are 2 disease interactions with Northera (droxidopa):
Droxidopa (Includes Northera) ↔ Ischemic Heart Disease/Arrhythmias/Chf
Moderate Potential Hazard, High plausibility
Applies to: Ischemic Heart Disease, Congestive Heart Failure, Arrhythmias, Hypertension
Droxidopa is directly metabolized in vivo to norepinephrine via decarboxylation. As such, it may exacerbate certain cardiovascular conditions by increasing blood pressure and heart rate. Therapy with droxidopa should be considered cautiously in patients with ischemic heart disease, arrhythmias, or congestive heart failure. Additionally, droxidopa may exacerbate supine hypertension in patients with neurogenic orthostatic hypotension. Patients should be advised to elevate the head of the bed while resting or sleeping. Blood pressure should be monitored both in supine position and the head- elevated sleeping position. If hypertension persists, then droxidopa dosage should be reduced or discontinued. If hypertension is not well managed, it can increase the risk of cardiovascular events, especially stroke.
Droxidopa (Includes Northera) ↔ Renal Impairment
Moderate Potential Hazard, Moderate plausibility
Applies to: Renal Dysfunction
Droxidopa and its metabolites is primarily cleared by the kidneys. Patients with mild and moderate renal impairment did not show adverse reactions in clinical trials. However, the clinical experience in patients with severe renal function (GFR < 30 mL/min) is limited. Caution is advised in patients with severe renal impairment.
Northera (droxidopa) drug Interactions
There are 353 drug interactions with Northera (droxidopa)
Northera (droxidopa) alcohol/food Interactions
There is 1 alcohol/food interaction with Northera (droxidopa)
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.
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