Skip to Content

Northera Side Effects

Generic Name: droxidopa

Note: This page contains side effects data for the generic drug droxidopa. It is possible that some of the dosage forms included below may not apply to the brand name Northera.

In Summary

More frequent side effects include: hypertension. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to droxidopa: oral capsule

As well as its needed effects, droxidopa (the active ingredient contained in Northera) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking droxidopa, check with your doctor immediately:

More common:
  • Bladder pain
  • bloody or cloudy urine
  • blurred vision
  • difficult, burning, or painful urination
  • dizziness
  • fainting
  • frequent urge to urinate
  • lower back or side pain
  • nervousness
  • pounding in the ears
  • slow or fast heartbeat

Minor Side Effects

Some droxidopa side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Headache
  • nausea

For Healthcare Professionals

Applies to droxidopa: oral capsule


Common (1% to 10%): Hypertension (greater than 5%)
Frequency not reported: Supine hypertension, exacerbation of existing heart disease, arrhythmias, and congestive heart failure[Ref]


Common (1% to 10%): Nausea[Ref]


Very common (10% or more): Urinary tract infections (15% in the elderly)[Ref]


Very common (10% or more): Falls (24% in the elderly)[Ref]

Nervous system

Very common (10% or more): Headache (up to 15%), syncope (13% in the elderly), dizziness (up to 11%)[Ref]


1. "Product Information. Northera (droxidopa)." Chelsea Therapeutics Inc, Charlotte, NC.

It is possible that some side effects of Northera may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.