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Northera Side Effects

Generic name: droxidopa

Medically reviewed by Last updated on Mar 26, 2022.

Note: This document contains side effect information about droxidopa. Some of the dosage forms listed on this page may not apply to the brand name Northera.


More frequent side effects include: hypertension. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to droxidopa: oral capsule


Oral route (Capsule)

Monitor supine blood pressure before and during treatment, and more frequently when increasing doses. Elevating the head of the bed lessens the risk of supine hypertension and blood pressure should be measured in this position. If supine hypertension cannot be managed by elevating the head of the bed, reduce or discontinue droxidopa.

Side effects requiring immediate medical attention

Along with its needed effects, droxidopa (the active ingredient contained in Northera) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking droxidopa:

More common

  • Bladder pain
  • bloody or cloudy urine
  • blurred vision
  • difficult, burning, or painful urination
  • dizziness
  • fainting
  • frequent urge to urinate
  • lower back or side pain
  • nervousness
  • pounding in the ears
  • slow or fast heartbeat

Side effects not requiring immediate medical attention

Some side effects of droxidopa may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to droxidopa: oral capsule


Common (1% to 10%): Hypertension (greater than 5%)

Frequency not reported: Supine hypertension, exacerbation of existing heart disease, arrhythmias, and congestive heart failure[Ref]


Common (1% to 10%): Nausea[Ref]


Very common (10% or more): Urinary tract infections (15% in the elderly)[Ref]


Very common (10% or more): Falls (24% in the elderly)[Ref]

Nervous system

Very common (10% or more): Headache (up to 15%), syncope (13% in the elderly), dizziness (up to 11%)[Ref]


1. "Product Information. Northera (droxidopa)." Chelsea Therapeutics Inc (2014):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.