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Vizimpro (dacomitinib) Disease Interactions

There are 2 disease interactions with Vizimpro (dacomitinib):

Moderate

Dacomitinib (applies to Vizimpro) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

The recommended dose of dacomitinib has not been established for patients with severe renal impairment (CrCl <30 mL/min). Caution is advised if used in these patients. No dose adjustment is recommended for patients with mild or moderate renal impairment.

Moderate

Dacomitinib (applies to Vizimpro) severe hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

The recommended dose of dacomitinib has not been established for patients with severe hepatic impairment (total bilirubin > 3 to 10 × ULN and any AST). Caution is advised if used in these patients. No dose adjustment is recommended in patients with mild or moderate hepatic impairment.

Vizimpro (dacomitinib) drug interactions

There are 91 drug interactions with Vizimpro (dacomitinib)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.