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Clofarabine Disease Interactions

There are 5 disease interactions with clofarabine:

Major

Clofarabine (applies to clofarabine) sepsis

Major Potential Hazard, Moderate plausibility. Applicable conditions: Tumor Lysis Syndrome, Infection - Bacterial/Fungal/Protozoal/Viral

Clofarabine injection may cause acute renal failure. Patients with infection, sepsis, or tumor lysis syndrome may be at increased risk of renal toxicity when treated with clofarabine injection. It is recommended to monitor patients for renal toxicity and interrupt or discontinue clofarabine injection as necessary.

Moderate

Clofarabine (applies to clofarabine) enterocolitis

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Colitis/Enteritis (Noninfectious)

Fatal and serious cases of enterocolitis, including neutropenic colitis, cecitis, and C. difficile colitis, have occurred during treatment with clofarabine. This has occurred more frequently within 30 days of treatment, and in the setting of combination chemotherapy. Enterocolitis may lead to necrosis, perforation, hemorrhage or sepsis complications. Monitor patients for signs and symptoms of enterocolitis and treat promptly. Care should be exercised when treating patients presenting with symptoms of enterocolitis.

Moderate

Clofarabine (applies to clofarabine) hepatic disease

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Severe and fatal hepatotoxicity, including hepatitis and hepatic failure, has occurred with the use of clofarabine. Monitor hepatic function and for signs and symptoms of hepatitis and hepatic failure. It is recommended to discontinue clofarabine immediately for Grade 3 or greater liver enzyme and/or bilirubin elevation of the liver, or veno-occlusive disease is suspected. Care should be exercised when using this agent in patients with liver disease.

Moderate

Clofarabine (applies to clofarabine) myelosuppression

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Bone Marrow Depression/Low Blood Counts

Clofarabine causes myelosuppression which may be severe and prolonged. Serious and fatal hemorrhage, including cerebral, gastrointestinal and pulmonary hemorrhage associated with thrombocytopenia has occurred. It is recommended to monitor complete blood counts including platelets and coagulation parameters and treat accordingly. Care should be exercised when using this agent in patients with bone marrow depression.

Moderate

Clofarabine (applies to clofarabine) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

The use of clofarabine may cause acute renal failure. It is recommended to reduce the dose by 50% in patients with CrCl of 30 to 60 mL/min. At this time the manufacturer is not able to make a dosage recommendation in patients with CrCl less than 30 mL/min or in those on dialysis as there is insufficient information in this patient population. Care should be exercised when using this agent in patients with renal dysfunction.

Clofarabine drug interactions

There are 506 drug interactions with clofarabine

Clofarabine alcohol/food interactions

There is 1 alcohol/food interaction with clofarabine

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.