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Blinatumomab Disease Interactions

There are 8 disease interactions with blinatumomab.

Major

Blinatumomab (applies to blinatumomab) vaccination

Major Potential Hazard, Moderate plausibility.

The administration of live vaccines should be avoided during therapy with blinatumomab. Vaccination with live virus vaccines is not recommended for at least 2 weeks prior to start of therapy, during treatment, and until the immune system has recovered following last cycle of blinatumomab. It is recommended to be up-to-date with all required immunizations, as recommended by current immunization guidelines, before initiating therapy.

Moderate

Blinatumomab (applies to blinatumomab) leukoencephalopathy

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: History - Radiation Therapy

Cranial MRI changes showing leukoencephalopathy have been observed in patients receiving blinatumomab, especially in patients with prior treatment with cranial irradiation and antileukemic chemotherapy (including systemic high-dose methotrexate or intrathecal cytarabine). The clinical significance of these imaging changes is unknown.

Moderate

Blinatumomab (applies to blinatumomab) liver dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

No formal pharmacokinetic studies have been conducted in patients with hepatic impairment. Data has indicated that there are no clinically significant differences in exposure to blinatumomab based on mild or moderate hepatic impairment.

Moderate

Blinatumomab (applies to blinatumomab) metabolic acidosis

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Prematurity/Underweight in Infancy

Some formulations of blinatumomab contain benzyl alcohol (a preservative). Pediatric patients with immature pathways for alcohol metabolism or with underlying conditions that could predispose to acid base imbalance may be at risk for serious adverse reactions, including fatal reactions and the "gasping syndrome". Early preterm very low birth weight neonates (less than 1500 g) may be at higher risk. Use the preservative-free preparations of blinatumomab where possible in neonates and consider the combined daily metabolic load of benzyl alcohol from all sources. Monitor neonatal patients receiving blinatumomab with preservative for new or worsening metabolic acidosis.

Moderate

Blinatumomab (applies to blinatumomab) neurologic disorders

Moderate Potential Hazard, Moderate plausibility.

Blinatumomab may cause serious or life-threatening neurologic toxicity, including immune effector cell-associated neurotoxicity syndrome. There is limited experience with blinatumomab in patients with active acute lymphoblastic leukemia in the CNS or a history of neurologic events. Patients with a history or presence of clinically relevant CNS pathology were excluded from clinical studies.

Moderate

Blinatumomab (applies to blinatumomab) neutropenia

Moderate Potential Hazard, Moderate plausibility.

The use of blinatumomab may cause life-threatening neutropenia, and febrile neutropenia. It is recommended to monitor complete blood counts during the infusion. Therapy interruption is recommended for prolonged neutropenia. Care and close monitoring is recommended, in particular for any episodes of fever.

Moderate

Blinatumomab (applies to blinatumomab) pancreatitis

Moderate Potential Hazard, Moderate plausibility.

Fatal pancreatitis has been observed in patients treated with blinatumomab in combination with dexamethasone. Care should be exercised when using blinatumomab in combination with dexamethasone in patients with pancreatic disorders. Management of pancreatitis may require either temporary interruption or discontinuation of these agents.

Minor

Blinatumomab (applies to blinatumomab) renal impairment

Minor Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

No formal pharmacokinetic (PK) studies of blinatumomab have been conducted in patients with renal impairment. There is no data available in patients with severe renal impairment (CrCl 15 to 29 mL/min) or in patients on hemodialysis. PK analyses in patients with moderate renal impairment (CrCl 30 to 59 mL/min) determined blinatumomab clearance to be essentially within the range observed in patients with normal renal function.

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Blinatumomab drug interactions

There are 273 drug interactions with blinatumomab.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.