Bivalirudin Disease Interactions
There are 2 disease interactions with bivalirudin.
Thrombin inhibitors (applies to bivalirudin) active bleeding
Major Potential Hazard, High plausibility. Applicable conditions: Coagulation Defect
The use of thrombin inhibitors is contraindicated in the presence of active major bleeding. Additionally, these drugs should be used with caution in patients with disease states associated with an increased risk of bleeding.
Bivalirudin (applies to bivalirudin) renal impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
Clinical studies showed that the clearance of bivalirudin is reduced approximately 20% with moderate and severe renal impairment and is reduced about 80% in dialysis-dependent patients. The infusion dose of bivalirudin may need to be reduced, and anticoagulant status monitored in patients with renal impairment.
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Bivalirudin drug interactions
There are 159 drug interactions with bivalirudin.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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