Aprotinin Disease Interactions

Administration of aprotinin (following an initial test dose) can result in anaphylaxis. The risk of anaphylaxis is increased when re-exposure occurs within six months of initial aprotinin therapy. Therapy with aprotinin should be administered cautiously in patients with significant allergies to other drugs or substances, since they may be at increased risk of developing an allergic reaction to aprotinin.

The effect of renal impairment on the pharmacokinetic disposition of aprotinin has not been fully determined. During clinical trials, mild renal impairment did not substantially alter the elimination of aprotinin. However, aprotinin is primarily eliminated by the kidney and dosage reductions in patients with severe renal dysfunction may be necessary .