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Sodium sulfate, magnesium sulfate, and potassium chloride (Oral)

Medically reviewed by Drugs.com. Last updated on Sep 25, 2022.

Commonly used brand name(s)

In the U.S.

  • Sutab

Available Dosage Forms:

  • Tablet

Therapeutic Class: Laxative, Hyperosmotic

Uses for sodium sulfate, magnesium sulfate, and potassium chloride

Sodium sulfate, magnesium sulfate, and potassium chloride combination is used to cleanse the colon (bowel) before a colonoscopy. Sodium sulfate, magnesium sulfate, and potassium chloride is a laxative. It works by causing you to have diarrhea to clean your colon. Cleaning your colon will help your doctor see the inside of your colon more clearly during colonoscopy.

Sodium sulfate, magnesium sulfate, and potassium chloride is available only with your doctor's prescription.

Before using sodium sulfate, magnesium sulfate, and potassium chloride

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For sodium sulfate, magnesium sulfate, and potassium chloride, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to sodium sulfate, magnesium sulfate, and potassium chloride or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of sodium sulfate, magnesium sulfate, and potassium chloride combination in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of sodium sulfate, magnesium sulfate, and potassium chloride combination in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, and unwanted effects (eg, fluid or electrolyte imbalance), which may require caution in patients receiving sodium sulfate, magnesium sulfate, and potassium chloride.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking sodium sulfate, magnesium sulfate, and potassium chloride, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using sodium sulfate, magnesium sulfate, and potassium chloride with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Amantadine
  • Atropine
  • Belladonna
  • Belladonna Alkaloids
  • Benztropine
  • Biperiden
  • Clidinium
  • Darifenacin
  • Dicyclomine
  • Eplerenone
  • Fesoterodine
  • Glycopyrrolate
  • Hyoscyamine
  • Methscopolamine
  • Oxybutynin
  • Procyclidine
  • Scopolamine
  • Solifenacin
  • Tolterodine
  • Trihexyphenidyl
  • Trospium

Using sodium sulfate, magnesium sulfate, and potassium chloride with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Alacepril
  • Amiloride
  • Baloxavir Marboxil
  • Benazepril
  • Bictegravir
  • Bisacodyl
  • Canrenoate
  • Captopril
  • Chlorpromazine
  • Chlortetracycline
  • Cilazapril
  • Ciprofloxacin
  • Delafloxacin
  • Delapril
  • Demeclocycline
  • Digoxin
  • Dolutegravir
  • Doxycycline
  • Eltrombopag
  • Elvitegravir
  • Enoxacin
  • Eravacycline
  • Fosinopril
  • Gatifloxacin
  • Gemifloxacin
  • Grepafloxacin
  • Imidapril
  • Indomethacin
  • Iron
  • Levofloxacin
  • Levomethadyl
  • Licorice
  • Lisinopril
  • Lomefloxacin
  • Lymecycline
  • Meclocycline
  • Methacycline
  • Minocycline
  • Moexipril
  • Moxifloxacin
  • Norfloxacin
  • Ofloxacin
  • Omadacycline
  • Oxytetracycline
  • Penicillamine
  • Pentopril
  • Perindopril
  • Quinapril
  • Raltegravir
  • Ramipril
  • Rolitetracycline
  • Sarecycline
  • Senna
  • Sodium Picosulfate
  • Sparfloxacin
  • Spirapril
  • Spironolactone
  • Temocapril
  • Tetracycline
  • Tigecycline
  • Trandolapril
  • Triamterene
  • Trovafloxacin
  • Zofenopril

Using sodium sulfate, magnesium sulfate, and potassium chloride with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Delafloxacin
  • Felodipine
  • Isradipine
  • Licorice
  • Nicardipine

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of sodium sulfate, magnesium sulfate, and potassium chloride. Make sure you tell your doctor if you have any other medical problems, especially:

  • Angina (chest pain), unstable or
  • Congestive heart failure or
  • Electrolyte imbalance (eg, low calcium, magnesium, potassium, sodium in the blood) or
  • Fluid imbalance or
  • Heart attack, recent or
  • Heart disease (eg, cardiomyopathy) or
  • Heart rhythm problems (eg, prolonged QT interval, uncontrolled arrhythmia), history of or
  • Withdrawal from alcohol or benzodiazepines—May increase risk for seizures, arrhythmia, or kidney problems.
  • Dehydration or
  • Inflammatory bowel disease or
  • Kidney disease or
  • Seizures, history of or
  • Trouble swallowing or
  • Ulcerative colitis, active and severe—Use with caution. May make these conditions worse.
  • Gastric retention (problems with emptying of food or fluid from the stomach) or
  • Intestinal problems (eg, blockage, ileus, perforation) or
  • Toxic colitis or
  • Toxic megacolon (a very dilated intestine)—Should not be used in patients with these conditions.

Proper use of sodium sulfate, magnesium sulfate, and potassium chloride

Your doctor may have special instructions for you, depending on the schedule of your colonoscopy you are going to have. If you have not received such instructions, or if you do not understand them, check with your doctor in advance.

Take sodium sulfate, magnesium sulfate, and potassium chloride exactly as directed. Otherwise, the test you are going to have may not work and may have to be done again.

Sodium sulfate, magnesium sulfate, and potassium chloride comes with a Medication Guide. You must read, understand, and follow these instructions carefully. Ask your doctor if you have any questions.

It is best if you do not eat any solid food before taking sodium sulfate, magnesium sulfate, and potassium chloride and until after your colonoscopy.

You may eat a low-residue breakfast (eg, eggs, white bread, cottage cheese, yogurt, grits, coffee, or tea) on the day before your colonoscopy.

After breakfast, drink only clear liquids all day and the next day until 2 hours before the time of your colonoscopy. Do not drink anything colored red or purple. Do not drink milk or alcohol.

To use the Sutab®:

  • The Sutab® contains 2 bottles (12 tablets each bottle), taken as a 2-day regimen (Split-dose method).
  • Early in the evening before the colonoscopy, open one bottle of 12 tablets.
  • Fill the given container with 16 ounces of water (up to the fill line). Swallow each tablet with a sip of water and drink the entire amount over 15 to 20 minutes.
  • One hour after swallowing the last tablet, fill the container for the second time with 16 ounces of water (up to the fill line) and drink the entire amount over 30 minutes. After 30 minutes, repeat the same step and drink over 30 minutes.
  • Then, on the morning of colonoscopy (5 to 8 hours before the test and at least 4 hours after the first dose), repeat the same steps and complete all Sutab® tablets and required amount of water at least 2 hours before the test.
  • If you have preparation-related symptoms (eg, nausea, bloating, cramping), you may pause or slow the rate of drinking the additional water until your symptoms stopped.
  • Do not eat or drink anything 2 hours prior to your colonoscopy, unless your doctor provides you with different instructions.

Avoid taking other laxatives (eg, bisacodyl, sodium picosulfate) while you are taking sodium sulfate, magnesium sulfate, and potassium chloride. Do not take any medicine by mouth within 1 hour before taking sodium sulfate, magnesium sulfate, and potassium chloride.

If you are taking chlorpromazine (Thorazine®), digoxin (Lanoxin®), iron supplements, penicillamine (Cuprimine®, Depen®), or tetracycline or fluoroquinolone antibiotics, take these medicines at least 2 hours before or 6 hours after taking Sutab®.

Dosing

The dose of sodium sulfate, magnesium sulfate, and potassium chloride will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of sodium sulfate, magnesium sulfate, and potassium chloride. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For cleansing the colon:
    • For oral dosage form (tablet):
      • Adults—
        • Dose 1: One bottle (12 tablets) taken early in the evening before colonoscopy.
        • Dose 2: One bottle (12 tablets) taken in the morning of the test, 5 to 8 hours before the colonoscopy.
      • Children—Use and dose must be determined by your doctor.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions while using sodium sulfate, magnesium sulfate, and potassium chloride

It is important that your doctor check you closely for any problems that may be caused by sodium sulfate, magnesium sulfate, and potassium chloride. Blood and urine tests may be needed to check for unwanted effects.

Call your doctor right away if you have decreased urination, dizziness, headache, or vomiting. These could be symptoms of a loss of too much body fluid (dehydration).

Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you had a heart rhythm problem, such as QT prolongation.

Sodium sulfate, magnesium sulfate, and potassium chloride may increase your risk for seizures. This is more likely to occur if you take medicine for depression, if you are withdrawing from alcohol or benzodiazepine use, or if you electrolyte imbalances (eg, low sodium, potassium, calcium, or magnesium in the blood). Talk to your doctor if you have any concerns.

Keep yourself hydrated before, during, and after using sodium sulfate, magnesium sulfate, and potassium chloride. Drink extra fluids so you will pass more urine. This may help prevent kidney problems.

Sodium sulfate, magnesium sulfate, and potassium chloride may cause serious bowel problems (eg, colon ulcers, ischemic colitis). Check with your doctor right away if you have stomach pain and tenderness, bloody stools, or rectal bleeding.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Sodium sulfate, magnesium sulfate, and potassium chloride side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

  • Dizziness
  • fainting
  • fast, slow, or uneven heartbeat

Incidence not known

  • Bloody stools
  • confusion
  • decreased urination
  • diarrhea
  • drowsiness
  • dry mouth
  • fainting
  • increase in heart rate
  • lightheadedness
  • loss of appetite
  • mood or mental changes
  • nausea
  • rapid breathing
  • rectal bleeding
  • seizures
  • stomach pain and tenderness
  • sunken eyes
  • swelling of the eyelids, face, lips, ankles, hands, or feet
  • thirst
  • trouble breathing
  • unusual tiredness or weakness
  • vomiting
  • wrinkled skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Full or bloated feeling
  • pressure in the stomach
  • swelling of the stomach area

Less common

  • Headache

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

More about magnesium sulfate / potassium chloride / sodium sulfate

Patient resources

Other brands

Sutab

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.