Skip to main content

Sacrosidase (Oral)

Generic name: sacrosidase [ sak-ROE-si-dase ]
Drug class: Digestive enzymes

Medically reviewed by Last updated on Nov 1, 2023.

Uses for sacrosidase

Sacrosidase is used to replace the sucrase enzyme in your body. This enzyme helps digest and absorb sucrose (sugar). It is used in certain conditions (e.g., congenital sucrase-isomaltase deficiency or CSID) where the body is not making enough sucrase.

This medicine is available only with your doctor's prescription.

Before using sacrosidase

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of sacrosidase in children and infants over 5 months of age.


No information is available on the relationship of age to the effects of sacrosidase in geriatric patients.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Diabetes—Use with caution. May make this condition worse.
  • Glycerin (glycerol) allergy or
  • Papain allergy or
  • Yeast allergy—Should not use in patients with these conditions.

Proper use of sacrosidase

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

You or your child might take the first and second dose of this medicine at your doctor's office. This is done to see if you or your child are allergic to the medicine.

This medicine comes with a patient information insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions.

Mix each dose of this medicine in 2 to 4 ounces (about 1/4 to 1/2 cup) of milk, water, or infant formula. Do not heat the medicine or mix it in warm or hot beverages. Hot liquids could cause it to break down and not work as well. Also, do not mix the medicine with fruit juice because the acid in the juice could cause it to break down.

Measure your dose by using the scoop that comes with the medicine or by counting the correct number of drops from the bottle. Rinse the dosing scoop with water after each use.

Take sacrosidase with meals or snacks. It is best to take about half of the dose at the beginning of the meal or snack and the rest at the end.

Your doctor may tell you or your child to limit the amount of starch that you eat. Carefully follow any special diet that your doctor gives you.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (solution):
    • To help digest sugar:
      • Adults, teenagers, and children weighing more than 15 kilograms (kg)—2 milliliters (mL) (56 drops) with each meal or snack during the day.
      • Children weighing up to 15 kg—1 mL (28 drops) with each meal or snack during the day.

Missed Dose

If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Store in the refrigerator. Do not freeze.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Throw away any unused medicine 4 weeks after opening the bottle. You should write down the date that you opened the medicine on the bottom of the bottle to help you remember.

Precautions while using sacrosidase

It is very important that your doctor check your progress at regular visits, to see if this medicine is working properly and to decide if you should continue to take it.

Sacrosidase may cause serious allergic reactions. Check with your doctor right away if you or your child have a rash; itching; swelling of the face, tongue, and throat; trouble with breathing; or chest pain after you use this medicine.

Your doctor may order a skin test before you or your child start using this medicine. The skin test is used to see if you have an allergy to sacrosidase. Tell your doctor if you or anyone in your home has ever had a positive skin test reaction to sacrosidase.

This medicine will help your body absorb sugar. This might change the level of sugar in your blood and urine. If you or your child have diabetes, you might need to measure your blood or urine sugar more often. Check with your doctor before changing your diet or the dose of your diabetes medicine.

Side Effects of sacrosidase

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

  • Chest pain
  • increase in heart rate
  • itching
  • nervousness
  • rapid breathing
  • rash
  • swelling of the face, tongue, and throat
  • wheezing or troubled breathing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Abdominal or stomach pain
  • confusion
  • constipation
  • decreased urination
  • diarrhea
  • dizziness
  • dry mouth
  • fainting
  • headache
  • increased thirst
  • lightheadedness
  • nausea and vomiting
  • sleeplessness
  • sunken eyes
  • thirst
  • trouble with sleeping
  • unable to sleep
  • unusual tiredness or weakness
  • wrinkled skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.