Protopam Chloride (Injection)
Generic Name: pralidoxime (Injection route)
Medically reviewed by Drugs.com. Last updated on Apr 20, 2019.
Commonly used brand name(s)
In the U.S.
- Protopam Chloride
Available Dosage Forms:
- Powder for Solution
Therapeutic Class: Nerve Gas Antidote
Uses for Protopam Chloride
Pralidoxime injection is used together with another medicine called atropine to treat poisoning caused by organic phosphorus pesticides (e.g., diazinon, malathion, mevinphos, parathion, and sarin) and by organophosphate chemicals (“nerve gases”) used in chemical warfare.
Pralidoxime injection is also used to treat overdose of medicines (e.g., ambenonium, neostigmine, pyridostigmine), that are used to treat myasthenia gravis. Poisoning with these chemicals or medicines causes your muscles, including the muscles that help you breathe, to become weak. Pralidoxime is used to help you get back strength in your muscles.
This medicine is to be given only by or under the direct supervision of a doctor or trained military personnel.
Before using Protopam Chloride
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of pralidoxime injection in children.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of pralidoxime injection in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving pralidoxime injection.
|All Trimesters||C||Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.|
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Interactions with food/tobacco/alcohol
Other medical problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
- Myasthenia gravis (severe muscle weakness)—Use with caution. May make this condition worse.
Proper use of Protopam Chloride
A nurse or other trained health professional will give you this medicine in a hospital or clinic. You may also be taught how to give your medicine at home. This medicine is preferably given through a needle placed in one of your veins. It may also be given as a shot under your skin or into a muscle.
This medicine is available in two forms: a vial and an autoinjector.
For patients using the pralidoxime autoinjector (automatic injection device):
- You will be trained to use the pralidoxime autoinjector by a medic or other trained military personnel. You will also be told the conditions under which it should be used.
- The autoinjector also comes with patient directions. Read them carefully before you actually need to use this medicine. Then, when an emergency arises, you will know how to inject the pralidoxime.
- It is important that you do not remove the safety cap on the autoinjector until you are ready to use it. This prevents spillage of the medicine from the device during storage and handling.
- To use the pralidoxime autoinjector:
- Remove the gray safety cap.
- Place the black tip of the device on the thigh, with the injector pointed straight at the thigh.
- Press hard into the thigh until the autoinjector functions. Hold in place for several seconds. Remove the autoinjector and dispose of it as directed.
- Massage the injected area for 10 seconds.
- For injection dosage form:
- For treatment of organic phosphorus pesticide poisoning:
- Adults and teenagers—At first, 1000 to 2000 milligrams (mg) injected into a vein usually as an infusion in 100 milliliters (mL) of normal saline, over a 15- to 30-minute period. The dose may be repeated after one hour, and then every eight to twelve hours if muscle weakness persists.
- Children and teenagers 16 years of age and younger—Dose is based on body weight and must be determined by your doctor. The dose is usually 20 to 50 milligrams (mg) per kilogram (kg) (9.07 to 22.7 mg per pound) of body weight injected into a vein. The dose may be repeated after one hour, and then every ten to twelve hours if muscle weakness persists.
- For treatment of organic phosphorus chemical (“nerve gas”) poisoning:
- Adults, teenagers, and children weighing 40 kilograms (kg) or more—600 milligrams (mg) or 2 milliliters (mL) injected into a muscle. The dose may be repeated fifteen minutes after the first dose and fifteen minutes after the second dose, if needed.
- Children and teenagers 16 years of age and younger weighing less than 40 kilograms (kg)—Dose is based on body weight and must be determined by your doctor. The dose is 15 milligrams (mg) per kilogram (kg) of body weight injected into the muscles of the thighs. The dose may be repeated fifteen minutes after the first dose and fifteen minutes after the second dose, if needed.
- For treatment of overdose of medicines used to treat myasthenia gravis:
- Adults and teenagers—At first, 1000 to 2000 milligrams (mg) injected into a vein. Then, 250 mg is injected into a vein every five minutes.
- Children—Use and dose must be determined by your doctor.
- For treatment of organic phosphorus pesticide poisoning:
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Precautions while using Protopam Chloride
Your doctor will check your progress closely while you or your child are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood tests may be needed to check for unwanted effects.
Call your doctor right away if you or your child have fast heartbeat, difficulty or trouble with breathing, increased muscle weakness, or severe tiredness after receiving this medicine.
This medicine will add to the effects of CNS depressants (medicines that may make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Protopam Chloride side effects
Check with your doctor or nurse immediately if any of the following side effects occur:
- Blurred or double vision
- change in near or distance vision
- difficult or rapid breathing
- difficulty in focusing the eyes
- difficulty with speaking
- fast, pounding, or irregular heartbeat or pulse
- muscle stiffness or weakness
- pain at the injection site (after injection into a muscle)
Incidence not known
- Deep or fast breathing with dizziness
- numbness of the feet, hands, and around the mouth
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More about Protopam Chloride (pralidoxime)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Pricing & Coupons
- En Español
- Drug class: antidotes
- FDA Alerts (1)