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Protopam Chloride Side Effects

Generic name: pralidoxime

Medically reviewed by Last updated on Jul 4, 2023.

Note: This document contains side effect information about pralidoxime. Some dosage forms listed on this page may not apply to the brand name Protopam Chloride.

Applies to pralidoxime: injection powder for solution.

Serious side effects of Protopam Chloride

Along with its needed effects, pralidoxime (the active ingredient contained in Protopam Chloride) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking pralidoxime:

More common

Incidence not known

Other side effects of Protopam Chloride

Some side effects of pralidoxime may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to pralidoxime: intravenous powder for injection.


Frequency not reported: Tachycardia, increased systolic and diastolic blood pressure[Ref]


Frequency not reported: Muscular weakness[Ref]

Nervous system

Frequency not reported: Drowsiness[Ref]


Frequency not reported: Hyperventilation[Ref]


Frequency not reported: Blurred vision, diplopia, impaired accommodation[Ref]


Frequency not reported: Nausea[Ref]


Frequency not reported: Transient elevations of creatine phosphokinase


SGOT and SGPT levels returned to normal after about 2 weeks.[Ref]

Frequency not reported: Elevations in SGOT and/or SGPT enzymes[Ref]


Frequency not reported: Pain at the injection site[Ref]

Mild to moderate pain at the injection site occurs 40 to 60 minutes after intramuscular injection.[Ref]


1. Product Information. Protopam Chloride (pralidoxime). Baxter Healthcare Corporation. 2001;PROD.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.