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Protopam Chloride Side Effects

Generic name: pralidoxime

Medically reviewed by Drugs.com. Last updated on Sep 22, 2024.

Note: This document provides detailed information about Protopam Chloride.

Applies to pralidoxime: injection powder for solution Side Effects associated with pralidoxime. Some dosage forms listed on this page may not apply specifically to the brand name Protopam Chloride.

Applies to pralidoxime: injection powder for solution.

Precautions

Your doctor will check your progress closely while you or your child are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood tests may be needed to check for unwanted effects.

Call your doctor right away if you or your child have fast heartbeat, difficulty or trouble with breathing, increased muscle weakness, or severe tiredness after receiving this medicine.

This medicine will add to the effects of CNS depressants (medicines that may make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Protopam Chloride

Along with its needed effects, pralidoxime (the active ingredient contained in Protopam Chloride) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking pralidoxime:

More common side effects

  • blurred or double vision
  • change in near or distance vision
  • difficult or rapid breathing
  • difficulty in focusing the eyes
  • difficulty with speaking
  • dizziness
  • fast, pounding, or irregular heartbeat or pulse
  • muscle stiffness or weakness
  • pain at the injection site (after injection into a muscle)

Incidence not known

  • deep or fast breathing with dizziness
  • numbness of the feet, hands, and around the mouth

Other side effects of Protopam Chloride

Some side effects of pralidoxime may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

For healthcare professionals

Applies to pralidoxime: intravenous powder for injection.

Cardiovascular adverse events

Musculoskeletal

Nervous system

Respiratory

Ocular

Gastrointestinal

Metabolic

Hepatic

SGOT and SGPT levels returned to normal after about 2 weeks.[Ref]

Local

Mild to moderate pain at the injection site occurs 40 to 60 minutes after intramuscular injection.[Ref]

See also:

References

1. (2001) "Product Information. Protopam Chloride (pralidoxime)." Baxter Healthcare Corporation

Further information

Protopam Chloride side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.