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perflutren protein type a microsphere (Intravenous route)

per-FLOO-tren PROE-teen type A MYE-kroe-sfeers

Intravenous route(Suspension)

Serious cardiopulmonary reactions, including fatalities, have occurred during or following perflutren-containing microsphere administration with the most serious reactions occurring within 30 minutes of administration. Assess all patients for any condition that precludes use of this product. Always have resuscitation equipment and trained personnel available .

Commonly used brand name(s)

In the U.S.

  • Optison

Available Dosage Forms:

  • Suspension

Therapeutic Class: Diagnostic Agent, Cardiac Function

Uses For perflutren protein type a microsphere

Perflutren protein type A microsphere injection is used during an echocardiogram to help diagnose or find problems in the heart.

Perflutren protein type A microsphere is an ultrasound contrast agent. Ultrasound contrast agents are used to help provide a clear picture during ultrasound. Ultrasound is a special kind of diagnostic procedure. It uses high-frequency sound waves to create images or “pictures” of certain areas inside the body. The sound waves produced by the ultrasound equipment can be reflected (bounced off) by different parts of the body, such as, the heart. As the sound waves return they are electronically converted into images on a television screen. Unlike x-rays, ultrasound does not involve ionizing radiation. The albumin microspheres sonicated preparation contains very small gas-filled albumin microspheres that reflect the sound waves and help create a better picture.

perflutren protein type a microsphere is to be given only by or under the direct supervision of a doctor with specialized training in ultrasound procedures.

Before Using perflutren protein type a microsphere

In deciding to use a diagnostic test, any risks of the test must be weighed against the good it will do. This is a decision you and your doctor will make. Also, other things may affect test results. For this test, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to perflutren protein type a microsphere or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of perflutren protein type A microsphere injection in the pediatric population. Safety and efficacy have not been established. .

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of perflutren protein type A microsphere injection in the elderly.

Pregnancy

Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this diagnostic test, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Receiving this diagnostic test with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Pasireotide

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this diagnostic test. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergy to albumin or
  • Allergy to blood or blood products—Should not be given to patients with these conditions.
  • Congenital heart defects or
  • Liver problems—Use is not recommended because its effect when these conditions are present is not known.
  • Congestive heart failure or
  • Heart attack or
  • Heart disease (eg, coronary artery syndrome) or
  • Heart rhythm problems (eg, ventricular arrhythmia) or
  • Heart shunt or
  • Lung disease—May increase risk for more serious side effects.

Proper Use of perflutren protein type a microsphere

A doctor or other trained health professional will give you perflutren protein type a microsphere. perflutren protein type a microsphere is given through a needle placed in one of your veins before the ultrasound.

Your doctor may have special instructions for you in preparation for your test. If you do not understand the instructions you receive or if you have not received such instructions, check with your doctor in advance.

Precautions While Using perflutren protein type a microsphere

It is very important that your doctor check your progress very closely while you are receiving perflutren protein type a microsphere. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.

Serious heart or lung problems may occur while you are receiving perflutren protein type a microsphere. Tell your doctor right away if you have a chest pain, fast, slow, pounding, or irregular heartbeat, lightheadedness, dizziness, or fainting, or troubled breathing.

perflutren protein type a microsphere may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving perflutren protein type a microsphere.

perflutren protein type a microsphere contains albumin, which is made from human blood. All donated blood is tested for certain viruses. Although your risk for getting a virus from the medicine is very low, talk with your doctor if you have concerns.

perflutren protein type a microsphere Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common
  • Chest pain
  • feeling of warmth
  • fever or chills
  • redness of the face, neck, arms, and occasionally, upper chest
  • trouble breathing
Rare
  • Hives or welts, itching, or skin rash
  • fast, irregular, pounding, or racing heartbeat or pulse
  • redness of the skin
Incidence not known
  • Blurred vision
  • chest discomfort
  • cold, clammy skin
  • confusion
  • convulsions
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • fast, weak pulse
  • feeling of warmth
  • headache
  • hoarseness
  • irritation
  • joint pain, stiffness, or swelling
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lightheadedness, dizziness, or fainting
  • nervousness
  • no blood pressure or pulse
  • noisy breathing
  • pounding in the ears
  • redness of the face, neck, arms, and occasionally, upper chest
  • stopping of heart
  • sweating
  • tightness in the chest
  • troubled swallowing
  • unconsciousness
  • unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Bad, unusual, or unpleasant (after) taste
  • change in taste
  • cough
  • discomfort at the injection site
  • nausea or vomiting
  • sore throat
  • stuffy or runny nose
Rare
  • Back pain
  • body or muscle aches
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in color vision
  • continuing ringing or buzzing or other unexplained noise in the ears
  • difficulty with moving
  • difficulty seeing at night
  • discoloration of the skin at the injection site
  • dry mouth
  • hearing loss
  • increased sensitivity of the eyes to sunlight
  • muscle pain or stiffness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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