Neomycin, polymyxin b, and gramicidin (Ophthalmic)
Generic name: gramicidin/neomycin/polymyxin b (nee-oh-MYE-sin SUL-fate, pol-ee-MIX-in B SUL-fate, gram-i-SYE-din)
Drug class: Ophthalmic anti-infectives
Medically reviewed by Drugs.com. Last updated on Jan 18, 2021.
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Antibiotic Combination
Chemical Class: Neomycin
Uses for neomycin, polymyxin b, and gramicidin
Neomycin, polymyxin B, and gramicidin is a combination antibiotic medicine used to treat infections of the eye.
Neomycin, polymyxin B, and gramicidin combination is available only with your doctor's prescription.
Before using neomycin, polymyxin b, and gramicidin
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For neomycin, polymyxin b, and gramicidin, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to neomycin, polymyxin b, and gramicidin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Studies on neomycin, polymyxin b, and gramicidin have been done only in adult patients, and there is no specific information comparing use of this combination in children with use in other age groups.
Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of neomycin, polymyxin B, and gramicidin combination in the elderly with use in other age groups.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Proper use of neomycin, polymyxin b, and gramicidin
The bottle is only partially full to provide proper drop control.
- First, wash your hands. Tilt the head back and, pressing your finger gently on the skin just beneath the lower eyelid, pull the lower eyelid away from the eye to make a space. Drop the medicine into this space. Let go of the eyelid and gently close the eyes. Do not blink. Keep the eyes closed for 1 or 2 minutes to allow the medicine to come into contact with the infection.
- If you think you did not get the drop of medicine into your eye properly, use another drop.
- To keep the medicine as germ-free as possible, do not touch the applicator tip or dropper to any surface (including the eye). Also, keep the container tightly closed.
To help clear up your infection completely, keep using neomycin, polymyxin b, and gramicidin for the full time of treatment, even if your symptoms have disappeared. Do not miss any doses.
The dose of neomycin, polymyxin b, and gramicidin will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of neomycin, polymyxin b, and gramicidin. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For eye infections:
- For eye drops dosage form:
- Adults and children—Use one drop in the eye two to four times a day for seven to ten days. If you have a more serious infection, your doctor may want you to use one drop in the eye every fifteen to thirty minutes at first. Then your doctor may have you use the medicine less often.
- For eye drops dosage form:
If you miss a dose of neomycin, polymyxin b, and gramicidin, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Precautions while using neomycin, polymyxin b, and gramicidin
If your symptoms do not improve within a few days, or if they become worse, check with your doctor.
Neomycin, polymyxin b, and gramicidin side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
- Itching, rash, redness, swelling, or other sign of irritation in or around the eye not present before use of neomycin, polymyxin b, and gramicidin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Burning or stinging sensation in the eye
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.