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elotuzumab (Intravenous route)

el-oh-TOOZ-ue-mab

Commonly used brand name(s)

In the U.S.

  • Empliciti

Available Dosage Forms:

  • Powder for Solution

Therapeutic Class: Antineoplastic Agent

Pharmacologic Class: Monoclonal Antibody

Uses For elotuzumab

Elotuzumab injection is used together with other medicines to treat multiple myeloma (a blood cell cancer) in patients who have received prior treatments. It interferes with the growth of cancer cells, which are then destroyed by the body. Elotuzumab is an antineoplastic agent (cancer medicine).

elotuzumab is to be given only by or under the direct supervision of your doctor.

Before Using elotuzumab

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For elotuzumab, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to elotuzumab or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of elotuzumab injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of elotuzumab injection in the elderly.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving elotuzumab, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using elotuzumab with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Measles Virus Vaccine, Live
  • Mumps Virus Vaccine, Live
  • Rubella Virus Vaccine, Live
  • Varicella Virus Vaccine

Using elotuzumab with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Adenovirus Vaccine
  • Bacillus of Calmette and Guerin Vaccine, Live
  • Cholera Vaccine, Live
  • Influenza Virus Vaccine, Live
  • Poliovirus Vaccine, Live
  • Smallpox Vaccine
  • Typhoid Vaccine
  • Yellow Fever Vaccine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of elotuzumab. Make sure you tell your doctor if you have any other medical problems, especially:

  • Infection—May decrease your body's ability to fight infections.
  • Liver disease—Use with caution. May make this condition worse.

Proper Use of elotuzumab

Medicines used to treat cancer are very strong and can have many side effects. Before receiving elotuzumab, make sure you understand all of the risks and benefits. It is important for you to work closely with your doctor during your treatment.

You will receive elotuzumab while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you elotuzumab. elotuzumab is given through a needle placed in one of your veins.

Your doctor may give you some medicines (eg, acetaminophen, diphenhydramine, ranitidine) to prevent infusion reactions.

elotuzumab should come with a patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Precautions While Using elotuzumab

It is very important that your doctor check you at regular visits to make sure that elotuzumab is working properly. Blood tests may be needed to check for unwanted effects.

Using elotuzumab together with lenalidomide while you are pregnant can harm your unborn baby. Men and women should use an effective form of birth control to prevent pregnancy during treatment. If you think a pregnancy has occurred while using the medicine, tell your doctor right away.

Infusion reactions may occur with elotuzumab. Tell your doctor right away if you have a skin rash, dizziness, fever or chills, a headache, nausea or vomiting, a slow or fast heartbeat, lightheadedness or fainting, sweating, or unusual tiredness or weakness.

Call your doctor right away if you have a cough that won't go away, weight loss, night sweats, fever, chills, or flu-like symptoms, such as a runny or stuffy nose, headache, or blurred vision. These may be symptoms of an infection.

Using elotuzumab may increase your risk of getting other types of cancer (including skin cancer). Talk to your doctor if you have concerns about this risk.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

elotuzumab Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common
  • Blurred vision
  • body aches or pain
  • chest pain
  • chills
  • confusion
  • cough or hoarseness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • ear congestion
  • facial swelling
  • fever or chills
  • headache
  • hives, itching, or rash
  • hoarseness
  • irritation
  • joint pain, stiffness, or swelling
  • loss of voice
  • lower back or side pain
  • nasal congestion
  • nausea or vomiting
  • nervousness
  • painful or difficult urination
  • pounding in the ears
  • redness of the skin
  • runny nose
  • slow or fast heartbeat
  • sneezing
  • sore throat
  • sweating
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • unusual tiredness or weakness
Less common
  • Abdominal pain or tenderness
  • clay-colored stools
  • dark urine
  • loss of appetite
  • persistent sore that does not heal
  • pink skin growth
  • reddish patch or irritated area
  • shiny skin bump
  • swelling of the feet or lower legs
  • white, yellow or waxy scar-like area on the skin
  • yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Blindness
  • burning, numbness, tingling, or painful sensations
  • decreased appetite
  • decreased vision
  • decreased weight
  • diarrhea
  • difficulty having a bowel movement (stool)
  • muscle aches
  • night sweats
  • pain in the arms or legs
  • unsteadiness or awkwardness
  • weakness in the arms, hands, legs, or feet

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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