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Anidulafungin (Intravenous)

Generic Name: anidulafungin (ay-nid-ue-la-FUN-jin)

Medically reviewed by Drugs.com. Last updated on Feb 12, 2021.

Commonly used brand name(s)

In the U.S.

  • Eraxis

Available Dosage Forms:

  • Powder for Solution

Therapeutic Class: Antifungal

Pharmacologic Class: Glucan Synthesis Inhibitor

Chemical Class: Echinocandin

Uses for anidulafungin

Anidulafungin is an antifungal medicine. It is used to treat fungal infections including candidemia (fungal infection in the blood), candida peritonitis and abscess (fungal infection in the stomach), esophageal candidiasis (fungal infection in the esophagus), and other fungal infections (including infections in the stomach).

Anidulafungin is to be given only by or under the direct supervision of a doctor.

Before using anidulafungin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For anidulafungin, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to anidulafungin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of anidulafungin injection in children younger than 1 month of age with candidemia or candida peritonitis and abscess. Safety and efficacy have not been established.

Appropriate studies have not been performed on the relationship of age to the effects of anidulafungin injection in children with esophageal candidiasis. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of anidulafungin injection in the elderly. However, elderly patients are more sensitive to the effects of anidulafungin than younger adults.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of anidulafungin. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergies to other echinocandin antifungal drugs (eg, caspofungin [Cancidas®], micafungin [Mycamine®])—Should not be used in patients with this condition.
  • Fructose intolerance (rare hereditary problem)—Should not be used in patients with this condition.
  • Liver disease—Use with caution. May make this condition worse.

Proper use of anidulafungin

A nurse or other trained health professional will give you anidulafungin. Anidulafungin is given through a needle placed in one of your veins. Anidulafungin is given slowly, so the needle will have to remain in place for 45 minutes to 3 hours.

Precautions while using anidulafungin

It is very important that your doctor check you closely while you are receiving anidulafungin. This is to make sure the medicine has worked properly. Blood tests may be needed to check for unwanted effects.

Check with your doctor right away if you or your child have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Anidulafungin may cause a serious type of allergic reaction called anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving anidulafungin.

Anidulafungin contains polysorbate 80, which can increase the risk for polysorbate toxicity in low-birth weight infants. Talk with your doctor if you have any concerns about this.

It is important to tell your doctor if you are pregnant or planning to become pregnant.

Anidulafungin side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common

  • Black, tarry stools
  • chills
  • cough
  • decreased urine
  • dry mouth
  • fever
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • lower back or side pain
  • mood or mental changes
  • muscle pain or cramps
  • nausea
  • numbness or tingling in the hands, feet or lips
  • painful or difficult urination
  • pale skin
  • seizures
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • trouble breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting

Rare

  • Back pain
  • bleeding gums
  • blood in the urine or stools
  • bloody stools
  • bluish color of skin
  • blurred or loss of vision
  • changes in skin color
  • chest pain or tightness
  • clay-colored stools
  • constipation
  • dark urine
  • depression
  • diarrhea
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • extra heartbeats
  • fainting
  • fast heartbeat
  • flushed, dry skin
  • flushing
  • fruit-like breath odor
  • headache
  • hives or welts
  • incoherent speech
  • increased hunger
  • increased urination
  • irregular fast heartbeat
  • irritability
  • itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • light-colored stools
  • metallic taste
  • muscle spasms (tetany) or twitching
  • muscle weakness
  • nervousness
  • pain, redness, or swelling in the arm or leg
  • pain, tenderness, and swelling of foot or leg
  • pinpoint red spots on the skin
  • pounding in the ears
  • redness of the skin
  • restlessness
  • skin rash
  • slow heartbeat
  • sore mouth or tongue
  • stomach pain
  • sweating
  • swelling of the feet or lower legs
  • swollen glands
  • trembling
  • unexplained weight loss
  • unpleasant breath odor
  • unusually warm skin
  • vomiting of blood
  • weakness
  • weight loss
  • white patches in the mouth or throat or on the tongue
  • white patches with diaper rash
  • yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

  • Acid or sour stomach
  • belching
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • disturbed color perception
  • double vision
  • eye pain
  • feeling of warmth
  • feeling unusually cold
  • halos around light
  • indigestion
  • loss of bowel control
  • night blindness
  • over bright appearance of lights
  • rapid weight gain
  • redness of the face, neck, arms, and occasionally, upper chest
  • shivering
  • stomach discomfort or upset
  • tingling of the hands or feet
  • tunnel vision
  • unusual weight gain or loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.